ArticlePloS one2015
Heterogeneity of ovarian theca and interstitial gland cells in mice.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Theca cells: active orchestrators of ovarian aging.Reproductive biology and endocrinology : RB&E · 2026Review
- The stromal microenvironment of ovary: a novel area in polycystic ovary syndrome.Journal of ovarian research · 2026Review
- Article
- Adrenal lipoma formation via PI(3,4,5)PProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Co-Expression of TWIK-Related Acid-Sensitive KBiomedicines · 2025Article
- Partial male-to-female reprogramming of mouse fetal testis by Sertoli cell ablation.Development (Cambridge, England) · 2023Article
- The injections of mitochondrial fusion promoter M1 during proestrus disrupt the progesterone secretion and the estrous cycle in the mouse.Scientific reports · 2023Article
- Intronic Enhancer Is Essential forInternational journal of molecular sciences · 2022Article
- VCAM1-α4β1 integrin interaction mediates interstitial tissue reconstruction in 3-D re-aggregate culture of dissociated prepubertal mouse testicular cells.Scientific reports · 2021Article
- Gene expression and functional abnormalities in XX/Sry Leydig cells.Scientific reports · 2021Article
- Osteoblast-activating peptide exhibits a specific distribution pattern in mouse ovary and may regulate ovarian steroids and local calcium levels.American journal of translational research · 2021Article
- Unique morphological characteristics in the ovary of cotton rat (Sigmodon hispidus).The Journal of reproduction and development · 2020Article
- Aberrant and constitutive expression of FOXL2 impairs ovarian development and functions in mice.Biology of reproduction · 2020Article
- The ovarian stroma as a new frontier.Reproduction (Cambridge, England) · 2020Review
- At the Crossroads of Fate-Somatic Cell Lineage Specification in the Fetal Gonad.Endocrine reviews · 2018Review
- Complete in vitro generation of fertile oocytes from mouse primordial germ cells.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- NR5A1 and cell population heterogeneity: Insights into developmental and functional disparities and regulatory mechanisms.Reproductive medicine and biologyReview
- Lipid droplet biogenesis in the ovary.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been established that two developmentally and functionally distinct cell types emerge within the mammalian testis and adrenal gland throughout life. Fetal and adult types of steroidogenic cells (i.e., testicular Leydig cells and adrenocortical cells) develop in the prenatal and postnatal period, respectively. Although the ovary synthesizes steroids postnatally, the presence of fetal-type steroidogenic cells has not been described. We had previously established transgenic mouse lines in which fetal Leydig cells were labeled with an EGFP reporter gene by the FLE (fetal Leydig enhancer) of the Ad4BP/SF-1 (Nr5a1) gene. In the present study, we examined the reporter gene expression in females and found that the reporter gene is turned on in postnatal ovaries. A comparison of the expressions of the EGFP and marker genes revealed that EGFP is expressed in not all but rather a proportion of steroidogenic theca and in interstitial gland cells in the ovary. This finding was further supported by experiments using BAC transgenic mice in which reporter gene expression recapitulated endogenous Ad4BP/SF-1 gene expression. In conclusion, our observations from this study strongly suggest that ovarian theca and interstitial gland cells in mice consist of at least two cell types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.