ArticleDiagnostic and interventional radiology (Ankara, Turkey)
Simple quantitative measurement based on DWI to objectively judge DWI-FLAIR mismatch in a canine stroke model.
Article in Diagnostic and interventional radiology (Ankara, Turkey). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Development and Testing of Thrombolytics in Stroke.Journal of stroke · 2021Review
- Imaging Ischemic and Hemorrhagic Disease of the Brain in Dogs.Frontiers in veterinary science · 2020Review
- Acute cerebrovascular event in a dog with polycythemia vera.The Canadian veterinary journal = La revue veterinaire canadienne · 2018Article
- Multimodal magnetic resonance imaging to identify stroke onset within 6 h in patients with large vessel occlusions.European stroke journal · 2018Article
- Temporal evolution of the signal intensity of hyper-acute ischemic lesions in a canine stroke model: influence of hyperintense acute reperfusion marker.Japanese journal of radiology · 2017Article
- High b value DWI in evaluation of the hyperacute cerebral ischemia at 3T: A comparative study in an embolic canine stroke model.Experimental and therapeutic medicine · 2016Article
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10 authors at 2 institutions in 1 country.
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Abstract
purposeDiffusion-weighted imaging (DWI) - fluid attenuated inversion recovery (FLAIR) mismatch was proven useful to time the onset of wake-up stroke; however, identifying the status of FLAIR imaging has been mostly subjective. We aimed to evaluate the value of relative DWI signal intensity (rDWI), and relative apparent diffusion coefficient (rADC) in identifying the FLAIR status in the acute period.
methodsAutologous clot was used to embolize left middle cerebral artery in 20 dogs. Magnetic resonance imaging was performed 3-6 hours and 24 hours after embolization. DWI-FLAIR mismatch was defined as hyperintense signal detected on DWI, but not on FLAIR. The mean values of rDWI or rADC of FLAIR- and FLAIR+ lesions were compared and the critical cutoff values of rDWI and rADC for identifying the FLAIR status were determined.
resultsStroke models were successfully established in all animals. DWI+ lesions were found in all 20 dogs from three hours, while FLAIR+ lesions were found in three, 11, 16, 19, and 20 dogs at five time points after embolization, respectively. The mean rDWI values were significantly different between FLAIR- and FLAIR+ lesions (P < 0.001), but rADC values were not (P = 0.73). Using rDWI=1.90 as the threshold value, excellent diagnostic efficacy was achieved (AUC, 0.88; sensitivity, 0.77; specificity, 0.88). However, rADC appeared not useful (AUC, 0.48; sensitivity, 0.52; specificity, 0.58) in identifying the FLAIR status.
conclusionIn our embolic canine stroke model, rDWI was useful to identify FLAIR imaging status in the acute period, while rADC was not.
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