Mapping of Replication Origins in the X Inactivation Center of Vole Microtus levis Reveals Extended Replication Initiation Zone.

Vladimir V Sherstyuk, Alexander I Shevchenko, Suren M Zakian

Erratum issuedOpen access · goldAbstract read

In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

0.5field-weighted citation impact, top 35% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

4 · The record

Corrections and comments

Erratum issued
Correction: Mapping of Replication Origins in the X Inactivation Center of Vole Microtus levis Reveals Extended Replication Initiation Zone.2015

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Vladimir V SherstyukInstitute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, Novosibirsk, Russia; State Research Institute of Circulation Pathology, Novosibirsk, Russia; Institute of Chemical Biology and Fundamental Medicine, Russian Academy of Sciences, Siberian Branch, Novosibirsk, Russia.

Alexander I ShevchenkoInstitute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, Novosibirsk, Russia; State Research Institute of Circulation Pathology, Novosibirsk, Russia; Institute of Chemical Biology and Fundamental Medicine, Russian Academy of Sciences, Siberian Branch, Novosibirsk, Russia.

Suren M ZakianInstitute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, Novosibirsk, Russia; State Research Institute of Circulation Pathology, Novosibirsk, Russia; Institute of Chemical Biology and Fundamental Medicine, Russian Academy of Sciences, Siberian Branch, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia.

Institute of Cytology and Genetics · RUNovosibirsk State University · RUSiberian Branch of the Russian Academy of Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA replication initiates at specific positions termed replication origins. Genome-wide studies of human replication origins have shown that origins are organized into replication initiation zones. However, only few replication initiation zones have been described so far. Moreover, few origins were mapped in other mammalian species besides human and mouse. Here we analyzed pattern of short nascent strands in the X inactivation center (XIC) of vole Microtus levis in fibroblasts, trophoblast stem cells, and extraembryonic endoderm stem cells and confirmed origins locations by ChIP approach. We found that replication could be initiated in a significant part of XIC. We also analyzed state of XIC chromatin in these cell types. We compared origin localization in the mouse and vole XIC. Interestingly, origins associated with gene promoters are conserved in these species. The data obtained allow us to suggest that the X inactivation center of M. levis is one extended replication initiation zone.

Indexed as

Chromosome MappingDNA ReplicationReplication OriginX Chromosome InactivationAnimalsArvicolinaeChromatinChromatin ImmunoprecipitationEndodermFibroblastsMicePromoter Regions, GeneticStem CellsTrophoblastsX ChromosomeChromatin

Identifiers

PMID26038842

DOI10.1371/journal.pone.0128497

PMCPMC4454516

OpenAlexW1497120985

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.