Trial reportPloS one2015
Alterations of Gray and White Matter Networks in Patients with Obsessive-Compulsive Disorder: A Multimodal Fusion Analysis of Structural MRI and DTI Using mCCA+jICA.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Cerebellar Microstructural Abnormalities in Obsessive-Compulsive Disorder (OCD): a Systematic Review of Diffusion Tensor Imaging Studies.Cerebellum (London, England) · 2024Pooled it
- Lucid Dreaming Frequency Associated With Grey-White Matter Networks: An Exploratory Multimodal MRI Study.Journal of sleep research · 2026Article
- Neuroimaging and Machine Learning in OCD: Advances in Diagnostic and Therapeutic Insights.Brain sciences · 2025Review
- Analysis of Longitudinal Change Patterns in Developing Brain Using Functional and Structural Magnetic Resonance Imaging via Multimodal Fusion.Human brain mapping · 2025Article
- The two sides of Phobos: Gray and white matter abnormalities in phobic individuals.Cognitive, affective & behavioral neuroscience · 2025Article
- Explaining cognitive function in multiple sclerosis through networks of grey and white matter features: a joint independent component analysis.Journal of neurology · 2025Article
- Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure.Molecular psychiatry · 2024Article
- Reduced GM-WM concentration inside the Default Mode Network in individuals with high emotional intelligence and low anxiety: a data fusion mCCA+jICA approach.Social cognitive and affective neuroscience · 2024Article
- High resolution 0.5mm isotropic TNeuroImage · 2023Article
- Relationship between white matter alterations and contamination subgroup in obsessive compulsive disorder: A diffusion tensor imaging study.Human brain mapping · 2023Article
- Data-driven multimodal fusion: approaches and applications in psychiatric research.Psychoradiology · 2023Review
- Development of high quality TNeuroImage · 2022Article
- An Examination of the Association Between Subjective Distress and Functional Connectivity During Discarding Decisions in Hoarding Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Cellular and Extracellular White Matter Abnormalities in Obsessive-Compulsive Disorder: A Diffusion Magnetic Resonance Imaging Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- White matter microstructure and its relation to clinical features of obsessive-compulsive disorder: findings from the ENIGMA OCD Working Group.Translational psychiatry · 2021Article
- White matter microstructural and Compulsive Sexual Behaviors Disorder - Diffusion Tensor Imaging study.Journal of behavioral addictions · 2021Review
- A Multimodal Fusion Analysis of Pretreatment Anatomical and Functional Cortical Abnormalities in Responsive and Non-responsive Schizophrenia.Frontiers in psychiatry · 2021Article
- Fusion analysis of gray matter and white matter in subjective cognitive decline and mild cognitive impairment by multimodal CCA-joint ICA.NeuroImage. Clinical · 2021Article
- Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography.Schizophrenia bulletin · 2020Article
- Linked 4-Way Multimodal Brain Differences in Schizophrenia in a Large Chinese Han Population.Schizophrenia bulletin · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many of previous neuroimaging studies on neuronal structures in patients with obsessive-compulsive disorder (OCD) used univariate statistical tests on unimodal imaging measurements. Although the univariate methods revealed important aberrance of local morphometry in OCD patients, the covariance structure of the anatomical alterations remains unclear. Motivated by recent developments of multivariate techniques in the neuroimaging field, we applied a fusion method called "mCCA+jICA" on multimodal structural data of T1-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) of 30 unmedicated patients with OCD and 34 healthy controls. Amongst six highly correlated multimodal networks (p < 0.0001), we found significant alterations of the interrelated gray and white matter networks over occipital and parietal cortices, frontal interhemispheric connections and cerebella (False Discovery Rate q ≤ 0.05). In addition, we found white matter networks around basal ganglia that correlated with a subdimension of OC symptoms, namely 'harm/checking' (q ≤ 0.05). The present study not only agrees with the previous unimodal findings of OCD, but also quantifies the association of the altered networks across imaging modalities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.