ArticleProceedings of the National Academy of Sciences of the United States of America2015
Retinal waves regulate afferent terminal targeting in the early visual pathway.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Nitric oxide refines retinal circuit architecture independently of retinal wave dynamics.Cell death discovery · 2026Article
- Retinal ganglion cell circuits and glial interactions in humans and mice.Trends in neurosciences · 2024Review
- Emergence of input selective recurrent dynamics via information transfer maximization.Scientific reports · 2024Article
- Development of ocular dominance columns across rodents and other species: revisiting the concept of critical period plasticity.Frontiers in neural circuits · 2024Review
- Retinal ganglion cell interactions shape the developing mammalian visual system.Development (Cambridge, England) · 2020Review
- Behavioral states modulate sensory processing in early development.Current sleep medicine reports · 2019Article
- Monocular enucleation alters retinal waves in the surviving eye.Neural development · 2018Article
- Spatiotemporal Features of Retinal Waves Instruct the Wiring of the Visual Circuitry.Frontiers in neural circuits · 2016Review
- Increasing Spontaneous Retinal Activity before Eye Opening Accelerates the Development of Geniculate Receptive Fields.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Current models of retinogeniculate development have proposed that connectivity between the retina and the dorsal lateral geniculate nucleus (dLGN) is established by gradients of axon guidance molecules, to allow initial coarse connections, and by competitive Hebbian-like processes, to drive eye-specific segregation and refine retinotopy. Here we show that when intereye competition is eliminated by monocular enucleation, blocking cholinergic stage II retinal waves disrupts the intraeye competition-mediated expansion of the retinogeniculate projection and results in the permanent disorganization of its laminae. This disruption of stage II retinal waves also causes long-term impacts on receptive field size and fine-scale retinotopy in the dLGN. Our results reveal a novel role for stage II retinal waves in regulating retinogeniculate afferent terminal targeting by way of intraeye competition, allowing for correct laminar patterning and the even allocation of synaptic territory. These findings should contribute to answering questions regarding the role of neural activity in guiding the establishment of neural circuits.
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Registered trials
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