ArticleProceedings of the National Academy of Sciences of the United States of America2015
Cell rejuvenation and social behaviors promoted by LPS exchange in myxobacteria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 60 citations in OpenAlex.
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- Cell-cell transfer of adaptation traits benefits kin and actor in a cooperative microbe.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Comprehensive Insights into Potential Metabolic Functions of Myxococcota in Activated Sludge Systems.Microbes and environments · 2024Article
- Two reasons to kill: predation and kin discrimination in myxobacteria.Microbiology (Reading, England) · 2023Review
- Bacterial secretion system functions: evidence of interactions and downstream implications.Microbiology (Reading, England) · 2023Article
- Predatory Strategies ofMicroorganisms · 2023Article
- Evaluation of Azido 3-Deoxy-d-ACS omega · 2022Article
- Nutritional stress induced intraspecies competition revealed by transcriptome analysis in Sphingomonas melonis TY.Applied microbiology and biotechnology · 2022Article
- Article
- Exploiting interbacterial antagonism for microbiome engineering.Current opinion in biomedical engineering · 2021Article
- Complementation inJournal of bacteriology · 2021Article
- Rapid diversification of wild social groups driven by toxin-immunity loci on mobile genetic elements.The ISME journal · 2020Article
- Polymorphic Toxins and Their Immunity Proteins: Diversity, Evolution, and Mechanisms of Delivery.Annual review of microbiology · 2020Review
- Kin recognition and outer membrane exchange (OME) in myxobacteria.Current opinion in microbiology · 2020Review
- The Fluidity of the Bacterial Outer Membrane Is Species Specific: Bacterial Lifestyles and the Emergence of a Fluid Outer Membrane.BioEssays : news and reviews in molecular, cellular and developmental biology · 2020Article
- Self-identity barcodes encoded by six expansive polymorphic toxin families discriminate kin in myxobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Direct visualization of a molecular handshake that governs kin recognition and tissue formation in myxobacteria.Nature communications · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Bacterial cells in their native environments must cope with factors that compromise the integrity of the cell. The mechanisms of coping with damage in a social or multicellular context are poorly understood. Here we investigated how a model social bacterium, Myxococcus xanthus, approaches this problem. We focused on the social behavior of outer membrane exchange (OME), in which cells transiently fuse and exchange their outer membrane (OM) contents. This behavior requires TraA, a homophilic cell surface receptor that identifies kin based on similarities in a polymorphic region, and the TraB cohort protein. As observed by electron microscopy, TraAB overexpression catalyzed a prefusion OM junction between cells. We then showed that damage sustained by the OM of one population was repaired by OME with a healthy population. Specifically, LPS mutants that were defective in motility and sporulation were rescued by OME with healthy donors. In addition, a mutant with a conditional lethal mutation in lpxC, an essential gene required for lipid A biosynthesis, was rescued by Tra-dependent interactions with a healthy population. Furthermore, lpxC cells with damaged OMs, which were more susceptible to antibiotics, had resistance conferred to them by OME with healthy donors. We also show that OME has beneficial fitness consequences to all cells. Here, in merged populations of damaged and healthy cells, OME catalyzed a dilution of OM damage, increasing developmental sporulation outcomes of the combined population by allowing it to reach a threshold density. We propose that OME is a mechanism that myxobacteria use to overcome cell damage and to transition to a multicellular organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.