ArticleEmerging microbes & infections2013
Integrated whole-genome sequencing and temporospatial analysis of a continuing Group A Streptococcus epidemic.
Article in Emerging microbes & infections, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Insights gained from sequencing Australian non-invasive and invasiveMicrobial genomics · 2024Article
- A Review ofPathogens (Basel, Switzerland) · 2021Review
- RocA Has Serotype-Specific Gene Regulatory and Pathogenesis Activities in Serotype M28 Group A Streptococcus.Infection and immunity · 2018Article
- Canada-Wide Epidemic ofOpen forum infectious diseases · 2018Article
- Community outbreaks of group A Streptococcus revealed by genome sequencing.Scientific reports · 2017Observational
- Epidemiological and Molecular Characterization of an Invasive Group A StreptococcusJournal of clinical microbiology · 2017Article
- Hypervirulent emm59 Clone in Invasive Group A Streptococcus Outbreak, Southwestern United States.Emerging infectious diseases · 2016Article
- High Incidence of Invasive Group A Streptococcus Disease Caused by Strains of Uncommon emm Types in Thunder Bay, Ontario, Canada.Journal of clinical microbiology · 2016Article
- The majority of 9,729 group A streptococcus strains causing disease secrete SpeB cysteine protease: pathogenesis implications.Infection and immunity · 2015Article
- Phosphorylation events in the multiple gene regulator of group A Streptococcus significantly influence global gene expression and virulence.Infection and immunity · 2015Article
- A naturally occurring single amino acid replacement in multiple gene regulator of group A Streptococcus significantly increases virulence.The American journal of pathology · 2015Article
- Clinical laboratory response to a mock outbreak of invasive bacterial infections: a preparedness study.Journal of clinical microbiology · 2014Article
- Spread of virulent group A Streptococcus type emm59 from Montana to Wyoming, USA.Emerging infectious diseases · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analysis of microbial epidemics has been revolutionized by whole-genome sequencing. We recently sequenced the genomes of 601 type emm59 Group A Streptococcus (GAS) organisms responsible for an ongoing epidemic of invasive infections in Canada and some of the United States. The epidemic has been caused by the emergence of a genetically distinct, hypervirulent clone that has genetically diversified. The ease of obtaining genomic data contrasts with the relatively difficult task of translating them into insightful epidemiological information. Here, we sequenced the genomes of 90 additional invasive Canadian emm59 GAS organisms, including 80 isolated recently in 2010-2011. We used an improved bioinformatics pipeline designed to rapidly process and analyze whole-genome data and integrate strain metadata. We discovered that emm59 GAS organisms are undergoing continued multiclonal evolutionary expansion. Previously identified geographic patterns of strain dissemination are being diluted as mixing of subclones over time and space occurs. Our integrated data analysis strategy permits prompt and accurate mapping of the dissemination of bacterial organisms in an epidemic wave, permitting rapid generation of hypotheses that inform public health and virulence studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.