Evidence map›Paper›PMID 26038424›Full record

ReviewEmerging microbes & infections2012

Receptor-binding domains of spike proteins of emerging or re-emerging viruses as targets for development of antiviral vaccines.

Shibo Jiang, Lu Lu, Qi Liu, Wei Xu, Lanying Du

Abstract readReview
In one paragraph

Review in Emerging microbes & infections, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Drug screening and development from the affinity of S protein of new coronavirus with ACE2.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Prospects for mucosal vaccine: shutting the door on SARS-CoV-2.Human vaccines & immunotherapeutics · 2020
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shibo JiangMOE/MOH Key Laboratory of Medical Molecular Virology, Shanghai Medical College and Institute of Medical Microbiology, Fudan University , Shanghai 200032, China ; Lindsley F. Kimball Research Institute, New York Blood Center , New York, NY 10065, USA.
Lu LuMOE/MOH Key Laboratory of Medical Molecular Virology, Shanghai Medical College and Institute of Medical Microbiology, Fudan University , Shanghai 200032, China.
Qi LiuMOE/MOH Key Laboratory of Medical Molecular Virology, Shanghai Medical College and Institute of Medical Microbiology, Fudan University , Shanghai 200032, China ; Department of Medical Microbiology and Immunology, School of Basic Medicine, Dali University , Dali 671000, China.
Wei XuMOE/MOH Key Laboratory of Medical Molecular Virology, Shanghai Medical College and Institute of Medical Microbiology, Fudan University , Shanghai 200032, China.
Lanying DuLindsley F. Kimball Research Institute, New York Blood Center , New York, NY 10065, USA.

Funding

SARS-CoV S Protein Receptor-binding Domain-based VaccinesR01AI068002 · NIAID · NEW YORK BLOOD CENTER · PI JIANG, SHIBO · 2007 to 2010
$1.5M
Rational design of M2e-FP conserved epitope-based universal influenza A vaccinesR03AI088449 · NIAID · NEW YORK BLOOD CENTER · PI DU, LANYING · 2011 to 2012
$162k
NIAID NIH HHS R01 AI068002NIAID NIH HHS R03 AI088449
6 · The paper itself

Abstract

A number of emerging and re-emerging viruses have caused epidemics or pandemics of infectious diseases leading to major devastations throughout human history. Therefore, developing effective and safe vaccines against these viruses is clearly important for the protection of at-risk populations. Our previous studies have shown that the receptor-binding domain (RBD) in the spike protein of severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) is a key target for the development of SARS vaccines. In this review, we highlight some key advances in the development of antiviral vaccines targeting the RBDs of spike proteins of emerging and re-emerging viruses, using SARS-CoV, influenza virus, Hendra virus (HeV) and Nipah virus (NiV) as examples.

Indexed as

Hendra virusinfluenza virusNipah virusreceptor-binding domainSARS-CoVspike proteinvaccinevirus

Identifiers

PMID26038424
PMCPMC3630917

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.