ReviewEmerging microbes & infections2012
Streptococcus pyogenes and re-emergence of scarlet fever as a public health problem.
Review in Emerging microbes & infections, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 87 citations in OpenAlex.
- Scarlet fever and meteorological exposures in Jiangsu, China: a time-stratified case-crossover study.BMC public health · 2025Article
- Molecular Characterization ofMicroorganisms · 2025Article
- Brain abscess caused by Streptococcus pyogenes with atypical symptoms: a case report and literature review.BMC pediatrics · 2024Review
- Invasive Streptococcal Infection in Children: An Italian Case Series.Children (Basel, Switzerland) · 2024Article
- Article
- Patterns in the Incidence of Scarlet Fever Among Children Aged 0-9 Years - China, 2010-2019.China CDC weekly · 2023Article
- Microbial Musings - Winter 2022.Microbiology (Reading, England) · 2022Article
- Clinical management and impact of scarlet fever in the modern era: findings from a cross-sectional study of cases in London, 2018-2019.BMJ open · 2021Article
- Streptococcal superantigens and the return of scarlet fever.PLoS pathogens · 2021Review
- Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis.Systematic reviews · 2021Article
- New Insights onFrontiers in microbiology · 2021Article
- Microbiota in Gut, Oral Cavity, and Mitral Valves Are Associated With Rheumatic Heart Disease.Frontiers in cellular and infection microbiology · 2021Article
- Tackling Multidrug Resistance in Streptococci - From Novel Biotherapeutic Strategies to Nanomedicines.Frontiers in microbiology · 2020Review
- Singularities of Pyogenic Streptococcal Biofilms - From Formation to Health Implication.Frontiers in microbiology · 2020Review
- An Evaluation of the Antibacterial Properties of Tormentic Acid Congener and Extracts FromAdvances in pharmacological and pharmaceutical sciences · 2020Article
- Epidemiological study of scarlet fever in Shenyang, China.BMC infectious diseases · 2019Article
- Analysis of Epidemiological Characteristics of Scarlet Fever in Zhejiang Province, China, 2004-2018.International journal of environmental research and public health · 2019Article
- Incidence of Scarlet Fever in Children in Jeju Province, Korea, 2002-2016: An Age-period-cohort Analysis.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2019Article
- A Dual-Replicon Shuttle Vector System for Heterologous Gene Expression in a Broad Range of Gram-Positive and Gram-Negative Bacteria.Current microbiology · 2018Article
- Resurgence of scarlet fever in China: a 13-year population-based surveillance study.The Lancet. Infectious diseases · 2018Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Explosive outbreaks of infectious diseases occasionally occur without immediately obvious epidemiological or microbiological explanations. Plague, cholera and Streptococcus pyogenes infection are some of the epidemic-prone bacterial infections. Besides epidemiological and conventional microbiological methods, the next-generation gene sequencing technology permits prompt detection of genomic and transcriptomic profiles associated with invasive phenotypes. Horizontal gene transfer due to mobile genetic elements carrying virulence factors and antimicrobial resistance, or mutations associated with the two component CovRS operon are important bacterial factors conferring survival advantage or invasiveness. The high incidence of scarlet fever in children less than 10 years old suggests that the lack of protective immunity is an important host factor. A high population density, overcrowded living environment and a low yearly rainfall are environmental factors contributing to outbreak development. Inappropriate antibiotic use is not only ineffective for treatment, but may actually drive an epidemic caused by drug-resistant strains and worsen patient outcomes by increasing the bacterial density at the site of infection and inducing toxin production. Surveillance of severe S. pyogenes infection is important because it can complicate concurrent chickenpox and influenza. Concomitant outbreaks of these two latter infections with a highly virulent and drug-resistant S. pyogenes strain can be disastrous.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.