Evidence map›Paper›PMID 26038402›Full record

ArticleEmerging microbes & infections2012

Naturally acquired Mycobacterium tuberculosis complex in laboratory pig-tailed macaques.

Gregory A Engel, Alicia K Wilbur, Andrew Westmark, Dara Horn, Jordan Johnson, Lisa Jones-Engel

Open access · goldAbstract read
In one paragraph

Article in Emerging microbes & infections, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Noninvasive Detection of Tuberculosis by Oral Swab Analysis.Journal of clinical microbiology · 2019
    Article
  7. Article
  8. Article
  9. Article
  10. How well do you know your monkey TB model?Journal of medical primatology · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gregory A EngelEvolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington , Seattle 98125, WA, USA ; Swedish/Cherry Hill Family Medicine , Seattle 98122, WA, USA.
Alicia K WilburEvolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington , Seattle 98125, WA, USA.
Andrew WestmarkEvolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington , Seattle 98125, WA, USA.
Dara HornEvolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington , Seattle 98125, WA, USA.
Jordan JohnsonEvolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington , Seattle 98125, WA, USA.
Lisa Jones-EngelEvolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington , Seattle 98125, WA, USA.
University of Washington · USSwedish Family Medicine Residency - Cherry Hill · US

Funding

YILMA SIV VACCINIA VACCINE TRIALP51RR000166 · NCRR · UNIVERSITY OF WASHINGTON · PI HU, SHIU-LOK · 1985 to 2011
$161.1M
Evolution and Emergence of Simian Retroviruses in South AsiaR01AI078229 · NIAID · UNIVERSITY OF WASHINGTON · PI BARRY, PETER A, ESCALANTE, ANANIAS ALBERTO · 2008 to 2012
$3.7M
NCRR NIH HHS P51 RR000166NIAID NIH HHS R01 AI078229
6 · The paper itself

Abstract

Here we present a case series from a primate research facility. The index case, a 4-year-old pig-tailed macaque (Macaca nemestrina) experimentally infected with chimeric simian-human immunodeficiency virus (SHIVSF162 P4), developed weight loss and was euthanized. Based on necropsy results the animal was diagnosed with opportunistic atypical mycobacteriosis associated with simian AIDS (SAIDS). Subsequently, tissues from the index animal, as well as tissues and oral mucosal swabs from six SHIV-infected contacts, were analyzed using molecular methods and found to contain nucleic acid sequences characteristic of Mycobacterium tuberculosis complex (MTBC). These data suggest that existing protocols fail to reliably detect MTBC infection in laboratory primates used as experimental models.

Indexed as

atypical mycobacteriosis; coinfection; IS6110; Macaca; MTBC; pig-tailed macaque; SHIVSF162 P4

Identifiers

PMID26038402
PMCPMC3636427
OpenAlexW2007850865

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.