ArticleThe British journal of ophthalmology2015
Fibrosis, gene expression and orbital inflammatory disease.
Article in The British journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Current insights of applying MRI in Graves' ophthalmopathy.Frontiers in endocrinology · 2022Pooled it
- Identification of key genes and metabolites in thyroid eye disease through integrated transcriptomic and metabolomic analysis.Frontiers in endocrinology · 2026Article
- Integrative analysis identifies shared therapeutic pathways in thyroid eye disease and diabetes mellitus.Scientific reports · 2025Article
- GPX1-driven selenium nanoplatform reprograms MAMs-mediated organelle crosstalk to reverse inflammatory adipose expansion in thyroid eye disease.Theranostics · 2025Article
- Article
- Nonspecific Orbital Inflammation (NSOI): Unraveling the Molecular Pathogenesis, Diagnostic Modalities, and Therapeutic Interventions.International journal of molecular sciences · 2024Review
- Orbital inflammatory pseudotumor: new advances in diagnosis, pathogenesis, and treatment.European journal of medical research · 2023Review
- Weak acid-initiated slow release of Dexamethasone from hydrogel to treat orbital inflammation.Theranostics · 2023Article
- Novel Insights into Pathophysiology of Orbital Inflammatory Diseases and Progression to Orbital Lymphoma by Pathway Enrichment Analysis.Life (Basel, Switzerland) · 2022Article
- Computed tomography-guided cutting needle biopsy for lung nodules: when the biopsy-based benign results are real benign.World journal of surgical oncology · 2022Article
- Clinical heterogeneity between two subgroups of patients with idiopathic orbital inflammation.BMJ open ophthalmology · 2022Article
- Fight against fibrosis in adipose tissue remodeling.American journal of physiology. Endocrinology and metabolism · 2021Review
- Computed tomography-guided biopsy of small lung nodules: diagnostic accuracy and analysis for true negatives.The Journal of international medical research · 2020Article
- Microarray Data of Lacrimal Gland Implicates Dysregulated Protein Processing in Endoplasmic Reticulum in Graves' Ophthalmopathy.Frontiers in endocrinology · 2020Article
- Asymmetric lacrimal gland enlargement: an indicator for detection of pathological entities other than thyroid eye disease.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Observational
- Combining micro-RNA and protein sequencing to detect robust biomarkers for Graves' disease and orbitopathy.Scientific reports · 2018Article
- The roles of Tenascin C and Fibronectin 1 in adhesive capsulitis: a pilot gene expression study.Clinics (Sao Paulo, Brazil) · 2016Article
- Extraocular Muscle Fibrosis in Idiopathic Orbital Inflammation.Journal of pediatric ophthalmology and strabismus · 2016Article
- Molecular diagnosis: Implications for ophthalmology.Progress in retinal and eye research · 2016Review
Corrections and comments
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Authors and funding
28 authors at 12 institutions in 4 countries.
Funding
Abstract
BACKGROUND/
aimsTo clarify the pathogenesis of fibrosis in inflammatory orbital diseases, we analysed the gene expression in orbital biopsies and compared our results with those reported for idiopathic pulmonary fibrosis.
methodsWe collected 140 biopsies from 138 patients (58 lacrimal glands; 82 orbital fat). Diagnoses included healthy controls (n=27), non-specific orbital inflammation (NSOI) (n=61), thyroid eye disease (TED) (n=29), sarcoidosis (n=14) and granulomatosis with polyangiitis (GPA) (n=7). Fibrosis was scored on a 0-3 scale by two experts, ophthalmic pathologists. Gene expression was quantified using Affymetrix U133 plus 2.0 microarray.
resultsWithin orbital fat, fibrosis was greatest among subjects with GPA (2.75±0.46) and significantly increased in tissue from subjects with GPA, NSOI or sarcoidosis (p<0.01), but not for TED, compared with healthy controls (1.13±0.69). For lacrimal gland, the average score among controls (1.36±0.48) did not differ statistically from any of the four disease groups. Seventy-three probe sets identified transcripts correlating with fibrosis in orbital fat (false discovery rate <0.05) after accounting for batch effects, disease type, age and sex. Transcripts with increased expression included fibronectin, lumican, thrombospondin and collagen types I and VIII, each of which has been reported upregulated in pulmonary fibrosis.
conclusionsA pathologist's recognition of fibrosis in orbital tissue correlates well with increased expression of transcripts that are considered essential in fibrosis. Many transcripts implicated in orbital fibrosis have been previously implicated in pulmonary fibrosis. TED differs from other causes of orbital fat inflammation because fibrosis is not a major component. Marked fibrosis is less common in the lacrimal gland compared with orbital adipose tissue.
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