ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2015
Association between body mass index and mortality for colorectal cancer survivors: overall and by tumor molecular phenotype.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Association of Obesity With Survival Outcomes in Patients With Cancer: A Systematic Review and Meta-analysis.JAMA network open · 2021Pooled it
- Phase II Feasibility Study of a Weight Loss Intervention in Female Breast and Colorectal Cancer Survivors (SWOG S1008).Obesity (Silver Spring, Md.) · 2018Trial
- The early-onset cancer epidemics: evidence synthesis using the prospective cohort incident-tumor biobank method.European journal of epidemiology · 2025Review
- Proceedings of the fifth international Molecular Pathological Epidemiology (MPE) meeting.Cancer causes & control : CCC · 2022Article
- A Bayesian approach to comparing common models of life-course epidemiology.International journal of epidemiology · 2021Article
- High body mass index is associated with an increased overall survival in rectal cancer.Journal of gastrointestinal oncology · 2020Article
- Proceedings of the fourth international molecular pathological epidemiology (MPE) meeting.Cancer causes & control : CCC · 2019Article
- Integration of microbiology, molecular pathology, and epidemiology: a new paradigm to explore the pathogenesis of microbiome-driven neoplasms.The Journal of pathology · 2019Review
- Insights into Pathogenic Interactions Among Environment, Host, and Tumor at the Crossroads of Molecular Pathology and Epidemiology.Annual review of pathology · 2019Review
- Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine.Gut · 2018Review
- Utility of inverse probability weighting in molecular pathological epidemiology.European journal of epidemiology · 2018Article
- Body Mass Index and Long-Term Outcomes in Patients With Colorectal Cancer.Frontiers in oncology · 2018Article
- Article
- Energy sensing pathways: Bridging type 2 diabetes and colorectal cancer?Journal of diabetes and its complications · 2017Review
- Prediagnostic alcohol consumption and colorectal cancer survival: The Colon Cancer Family Registry.Cancer · 2017Article
- Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status.European journal of epidemiology · 2017Article
- Molecular pathological epidemiology: new developing frontiers of big data science to study etiologies and pathogenesis.Journal of gastroenterology · 2017Review
- Proceedings of the third international molecular pathological epidemiology (MPE) meeting.Cancer causes & control : CCC · 2017Review
- Integration of pharmacology, molecular pathology, and population data science to support precision gastrointestinal oncology.NPJ precision oncology · 2017Article
- Article
Corrections and comments
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Authors and funding
28 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMicrosatellite instability (MSI) and BRAF mutation status are associated with colorectal cancer survival, whereas the role of body mass index (BMI) is less clear. We evaluated the association between BMI and colorectal cancer survival, overall and by strata of MSI, BRAF mutation, sex, and other factors.
methodsThis study included 5,615 men and women diagnosed with invasive colorectal cancer who were followed for mortality (maximum: 14.7 years; mean: 5.9 years). Prediagnosis BMI was derived from self-reported weight approximately one year before diagnosis and height. Tumor MSI and BRAF mutation status were available for 4,131 and 4,414 persons, respectively. Multivariable hazard ratios (HR) and 95% confidence intervals (CI) were estimated from delayed-entry Cox proportional hazards models.
resultsIn multivariable models, high prediagnosis BMI was associated with higher risk of all-cause mortality in both sexes (per 5-kg/m(2); HR, 1.10; 95% CI, 1.06-1.15), with similar associations stratified by sex (Pinteraction: 0.41), colon versus rectum (Pinteraction: 0.86), MSI status (Pinteraction: 0.84), and BRAF mutation status (Pinteraction: 0.28). In joint models, with MS-stable/MSI-low and normal BMI as the reference group, risk of death was higher for MS-stable/MSI-low and obese BMI (HR, 1.32; P value: 0.0002), not statistically significantly lower for MSI-high and normal BMI (HR, 0.86; P value: 0.29), and approximately the same for MSI-high and obese BMI (HR, 1.00; P value: 0.98).
conclusionsHigh prediagnosis BMI was associated with increased mortality; this association was consistent across participant subgroups, including strata of tumor molecular phenotype. IMPACT: High BMI may attenuate the survival benefit otherwise observed with MSI-high tumors.
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