ArticleBMJ open2015
Perinatal risk factors for premature ischaemic heart disease in a Swedish national cohort.
Article in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Childhood Risk Factors and Adulthood Cardiovascular Disease: A Systematic Review.The Journal of pediatrics · 2021Pooled it
- Preterm birth and mortality in adulthood: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2020Pooled it
- Birth Weight and Risk of Cardiovascular Disease Incidence in Adulthood: a Dose-Response Meta-analysis.Current atherosclerosis reports · 2020Pooled it
- Birth Weight and Risk of Type 2 Diabetes Mellitus, Cardiovascular Disease, and Hypertension in Adults: A Meta-Analysis of 7 646 267 Participants From 135 Studies.Journal of the American Heart Association · 2018Pooled it
- The Impact of Early-Life Growth on Long-Term Cardiometabolic and Neurocognitive Outcomes in High-Income Countries: A Neglected Public Health Problem.Nutrition reviews · 2026Review
- Foetal Metformin Exposure, Childhood Adiposity and Future Cardiovascular Risk: Can We Connect the Dots?TouchREVIEWS in endocrinology · 2025Review
- Assessing ambient air pollution's effects on birth outcomes: a Scottish IVF cohort study (2010 -2018).Environmental health : a global access science source · 2025Article
- Birth Weight, Gestational Age, and Risk of Cardiovascular Disease in Early Adulthood: Influence of Familial Factors.American journal of epidemiology · 2023Article
- Lower birth weight is linked to poorer cardiovascular health in middle-aged population-based adults.Heart (British Cardiac Society) · 2023Article
- Childhood cardiovascular morphology and function following abnormal fetal growth.Heart and vessels · 2022Article
- Exercise and hypoxia unmask pulmonary vascular disease and right ventricular dysfunction in a 10- to 12-week-old swine model of neonatal oxidative injury.The Journal of physiology · 2022Article
- Arterial health during early childhood following abnormal fetal growth.BMC pediatrics · 2022Article
- Postnatal Expression Profile of MicroRNAs Associated with Cardiovascular Diseases in 3- to 11-Year-Old Preterm-Born Children.Biomedicines · 2021Article
- An overview of adult health outcomes after preterm birth.Early human development · 2020Review
- The Density of Cell Nuclei at the Materno-Fetal Exchange Barrier is Sexually Dimorphic in Normal Placentas, but not in IUGR.Scientific reports · 2019Article
- Pregnancy-related conditions and premature coronary heart disease in adult offspring.Heart Asia · 2017Article
- Premature Adult Death in Individuals Born Preterm: A Sibling Comparison in a Prospective Nationwide Follow-Up Study.PloS one · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveSeveral studies have reported associations between restricted fetal development, as shown by birth weight or birth length, and later ischaemic heart disease (IHD). However, few studies have examined the importance of these perinatal factors when taking into account gestational age at birth, hereditary factors, sociodemographic factors and comorbidities. This study investigated the importance of perinatal risk factors for premature IHD and myocardial infarction (MI) in a large Swedish cohort. SETTING AND
participantsNational cohort study of 1,970,869 individuals who were live-born in Sweden in 1973 through 1992, and followed up to 2010 (ages 18-38 years). PRIMARY AND SECONDARY OUTCOME MEASURES: The main outcome was IHD, and the secondary outcome was MI.
resultsA total of 668 individuals were diagnosed with IHD in 18.8 million person-years of follow-up. After adjusting for gestational age at birth, sociodemographic factors, comorbidities and family history of IHD, low fetal growth was associated with increased risk of IHD (HR for <-2 vs -1 to <1 SD, 1.54; 95% CI 1.15 to 2.07; p=0.004) and increased risk of MI (HR for <-2 vs -1 to <1 SD, 2.48; 95% CI 1.66 to 3.71; p<0.001) in young adulthood. In contrast, gestational age at birth was not associated with the risk of IHD or MI.
conclusionsIn this large national cohort, low fetal growth was strongly associated with IHD and MI in young adulthood, independently of gestational age at birth, sociodemographic factors, comorbidities and family history of IHD.
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