ArticleNucleic acids research2015
PRC2 regulates RNA polymerase III transcribed non-translated RNA gene transcription through EZH2 and SUZ12 interaction with TFIIIC complex.
Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- The choreography of chromatin in RNA polymerase III regulation.Biochemical Society transactions · 2024Review
- TFIIIC as a Potential Epigenetic Modulator of Histone Acetylation in Human Stem Cells.International journal of molecular sciences · 2023Article
- Article
- A unique 15-bp InDel in the first intron of BMPR1B regulates its expression in Taihu pigs.BMC genomics · 2022Article
- Signal Recognition Particle in Human Diseases.Frontiers in genetics · 2022Article
- Targeting the regulation of aberrant protein production pathway in gastrointestinal cancer treatment.Frontiers in oncology · 2022Article
- HMGA1 promotes gastric cancer growth and metastasis by transactivating SUZ12 and CCDC43 expression.Aging · 2021Article
- Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.NAR cancer · 2021Article
- Epigenetic regulation of protein translation in KMT2A-rearranged AML.Experimental hematology · 2020Article
- RREB1-induced upregulation of the lncRNA AGAP2-AS1 regulates the proliferation and migration of pancreatic cancer partly through suppressing ANKRD1 and ANGPTL4.Cell death & disease · 2019Article
- A Novel lncRNA, LINC00460, Affects Cell Proliferation and Apoptosis by Regulating KLF2 and CUL4A Expression in Colorectal Cancer.Molecular therapy. Nucleic acids · 2018Article
- Structure of the PRC2 complex and application to drug discovery.Acta pharmacologica Sinica · 2017Review
- Current advances of long non-coding RNA highly upregulated in liver cancer in human tumors.OncoTargets and therapy · 2017Review
- TUG1: a pivotal oncogenic long non-coding RNA of human cancers.Cell proliferation · 2016Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycomb repression complex 2 (PRC2) component EZH2 tri-methylates H3K27 and exerts epigenetic repression on target gene expression. EZH2-mediated epigenetic control of RNA polymerase II (Pol II) transcribed coding gene transcription has been well established. However, little is known about EZH2-mediated epigenetic regulation of RNA polymerase III (Pol III) transcription. Here we present a paradigm that EZH2 is involved in the repression of Pol III transcription via interaction with transcriptional factor complex IIIC (TFIIIC). EZH2 and H3K27me3 co-occupy the promoter of tRNA(Tyr), 5S rRNA and 7SL RNA genes. Depletion of EZH2 or inhibition of EZH2 methyltransferase activity led to upregulation of Pol III target gene transcription. EZH2-mediated repression of Pol III transcribed gene expression requires presence of SUZ12. SUZ12 was able to interact with TFIIIC complex and knockdown of SUZ12 decreased occupancy of EZH2 and H3K27me3 at the promoter of Pol III target genes. Our findings pointed out a previously unidentified role of PRC2 complex in suppressing transcription of Pol III transcribed non-translated RNA genes, putting Pol III on a new layer of epigenetic regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.