Trial reportQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2015
The added effect of comorbidity on health-related quality of life in patients with asthma.
Trial report in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Validity and Responsiveness of EQ-5D in Asthma: A Systematic Review and Meta-analysis.The patient · 2025Pooled it
- Comorbidity and health-related quality of life in people with a chronic medical condition in randomised clinical trials: An individual participant data meta-analysis.PLoS medicine · 2023Pooled it
- Discerning asthma endotypes through comorbidity mapping.Nature communications · 2022Pooled it
- Health-related quality of life in adult patients with asthma according to asthma control and severity: A systematic review and meta-analysis.Frontiers in pharmacology · 2022Pooled it
- Sociodemographic determinants of multimorbidity in asthma: Insights from a retrospective cross-sectional study of the Obstructive Lung Disease program, Pakistan.Pakistan journal of medical sciences · 2026Article
- Health-related quality of life in asthma measured by the World Health Organization brief questionnaire (WHO-BREF) and the effect of concomitant allergic rhinitis-A population-based study.The clinical respiratory journal · 2025Article
- Impact of comorbidities on EQ-5D quality-of-life index in severe asthma.The journal of allergy and clinical immunology. Global · 2024Article
- Asthma and COPD management of patients with intellectual disabilities in general practice.NPJ primary care respiratory medicine · 2024Article
- Predictors of change in asthma-related quality of life: a longitudinal real-life study in adult asthmatics.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Relationship between Multimorbidity and Quality of Life in a Primary Care Setting: The Mediating Role of Dyspnea.Journal of clinical medicine · 2022Article
- Living with a chronic disease: A quantitative study of the views of patients with a chronic disease on the change in their life situation.SAGE open medicine · 2020Article
- Effect of asthma control on general health-related quality of life in patients diagnosed with adult-onset asthma.Scientific reports · 2019Article
- "Not Thinking that This Means the End When You Are Seriously Ill but Doing Something Positive about It"-A Qualitative Study of Living with a Life-Changing Disease.Diseases (Basel, Switzerland) · 2019Article
- Age- and sex-specific prevalence of chronic comorbidity in adult patients with asthma: A real-life study.NPJ primary care respiratory medicine · 2019Article
- EuroQol (EQ-5D-5L) Validity in Assessing the Quality of Life in Adults With Asthma: Cross-Sectional Study.Journal of medical Internet research · 2019Article
- Chronic Respiratory Disorders and Their Treatment among Older People with Intellectual Disability and/or Autism Spectrum Disorder in Comparison with the General Population.Healthcare (Basel, Switzerland) · 2017Article
- An Official American Thoracic Society Workshop Report: Evaluation and Management of Asthma in the Elderly.Annals of the American Thoracic Society · 2016Article
- The impact of comorbidities on productivity loss in asthma patients.Respiratory research · 2016Article
- Association between number of comorbid medical conditions and depression among individuals with diabetes; race and ethnic variations.Journal of diabetes and metabolic disorders · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo examine the effect of comorbidities on health-related quality of life (HRQoL) and their interaction with asthma control.
methodsIn a random sample of adults with asthma, we measured generic (EQ5D) and disease-specific (AQ5D) utility scores. Asthma symptom control was determined using the 2014 Global Initiative for Asthma Management Strategy. Comorbidity scores were calculated using a validated questionnaire. We used two-part regression models to measure the adjusted difference in utility across levels of symptom control and comorbidity scores and to examine the relative role of symptom control and comorbidity in explaining the variation in HRQoL.
resultsA total of 2,299 observations from 460 adult patients (mean age 52 years, 67 % women) were included. Compared to controlled asthma, uncontrolled asthma was associated with -0.018 reduction (95 % CI -0.028, -0.009) in EQ5D and -0.076 reduction (95 % CI -0.115, -0.052) in AQ5D utilities. An increase by one standard deviation in comorbidity score relative to the mean was associated with a change of -0.029 (95 % CI -0.043, -0.016) in EQ5D and -0.010 (95 % CI -0.020, -0.004) in AQLQ utilities. The impact of comorbidity was greater than asthma symptom control in explaining EQ5D variance (12 vs. 1 %) but smaller in explaining AQ5D variance (3 vs. 12 %).
conclusionsGeneric and disease-specific HRQoL instruments differentially capture the impact of symptom control and comorbidity in asthma. The selection of HRQoL instruments for asthma studies should depend on the prevalence of comorbidity in the target population and the impact of interventions on asthma control and comorbidity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.