ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015
Modeling Causal Relationship Between Brain Regions Within the Drug-Cue Processing Network in Chronic Cocaine Smokers.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- N-acetylcysteine reduces cocaine-seeking behavior and anterior cingulate glutamate/glutamine levels among cocaine-dependent individuals.Addiction biology · 2021Trial
- Neuroimaging as the 'missing link' for preclinical to clinical translation: an example using N-acetylcysteine among individuals with cocaine- and opioid-use disorders receiving methadone treatment.Psychopharmacology · 2026Article
- Immunosuppressant treatment reduces cocaine-induced behavioral sensitization in mice.Frontiers in pharmacology · 2026Article
- Cocaine Cues Used in Experimental Research: A Systematic Review.Brain sciences · 2025Review
- Mapping the Neural Substrates of Cocaine Craving: A Systematic Review.Brain sciences · 2024Review
- Causalized convergent cross-mapping and its approximate equivalence with directed information in causality analysis.PNAS nexus · 2024Article
- Optimizing Individual Targeting of Fronto-Amygdala Network with Transcranial Magnetic Stimulation (TMS): Biophysical, Physiological and Behavioral Variations in People with Methamphetamine Use Disorder.medRxiv : the preprint server for health sciences · 2023Article
- Altered prefrontal signaling during inhibitory control in a salient drug context in cocaine use disorder.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A serotonergic biobehavioral signature differentiates cocaine use disorder participants administered mirtazapine.Translational psychiatry · 2022Article
- The relationship between craving and insular morphometry in regular cocaine users: Does sex matter?Addiction biology · 2022Article
- Midcingulate Cortical Activations Interrelate Chronic Craving and Physiological Responses to Negative Emotions in Cocaine Addiction.Biological psychiatry global open science · 2021Article
- Noradrenergic correlates of chronic cocaine craving: neuromelanin and functional brain imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use disorder.Psychiatry research. Neuroimaging · 2019Article
- The thalamus in drug addiction: from rodents to humans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Altered anterior cingulate cortex to hippocampus effective connectivity in response to drug cues in men with cocaine use disorder.Psychiatry research. Neuroimaging · 2018Article
- Dynamic network dysfunction in cocaine dependence: Graph theoretical metrics and stop signal reaction time.NeuroImage. Clinical · 2018Article
- Neuroimaging Metrics of Drug and Food Processing in Cocaine-Dependence, as a Function of Psychopathic Traits and Substance Use Severity.Frontiers in human neuroscience · 2018Article
- Modeling Causal Relationships among Brain Areas in the Mesocorticolimbic System during Resting-State in Cocaine Users Utilizing a Graph Theoretic Approach.Journal of alcoholism and drug dependence · 2017Article
- Examining Brain Networks in Prescription Opioid Users.Journal of alcoholism and drug dependence · 2017Article
- Altered structural and effective connectivity in anorexia and bulimia nervosa in circuits that regulate energy and reward homeostasis.Translational psychiatry · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The cues associated with drugs of abuse have an essential role in perpetuating problematic use, yet effective connectivity or the causal interaction between brain regions mediating the processing of drug cues has not been defined. The aim of this fMRI study was to model the causal interaction between brain regions within the drug-cue processing network in chronic cocaine smokers and matched control participants during a cocaine-cue exposure task. Specifically, cocaine-smoking (15M; 5F) and healthy control (13M; 4F) participants viewed cocaine and neutral cues while in the scanner (a Siemens 3 T magnet). We examined whole brain activation, including activation related to drug-cue processing. Time series data extracted from ROIs determined through our General Linear Model (GLM) analysis and prior publications were used as input to IMaGES, a computationally powerful Bayesian search algorithm. During cocaine-cue exposure, cocaine users showed a particular feed-forward effective connectivity pattern between the ROIs of the drug-cue processing network (amygdala → hippocampus → dorsal striatum → insula → medial frontal cortex, dorsolateral prefrontal cortex, anterior cingulate cortex) that was not present when the controls viewed the cocaine cues. Cocaine craving ratings positively correlated with the strength of the causal influence of the insula on the dorsolateral prefrontal cortex in cocaine users. This study is the first demonstration of a causal interaction between ROIs within the drug-cue processing network in cocaine users. This study provides insight into the mechanism underlying continued substance use and has implications for monitoring treatment response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.