ArticleBiophysical journal2015
Experiments on Hemoglobin in Single Crystals and Silica Gels Distinguish among Allosteric Models.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Analysis of β-C-terminal salt bridges in T-state hemoglobin by trapping tertiary conformations in silica gels.Protein science : a publication of the Protein Society · 2025Article
- Uncovering the Role of Distal Regions in PDK1 Allosteric Activation.ACS bio & med chem Au · 2025Article
- Effects of allosteric effectors on oxygen binding to crystals of hemoglobin in the R-quaternary structure.Protein science : a publication of the Protein Society · 2025Article
- Wandering about allostery.Biology direct · 2024Article
- Article
- Modulation of Allosteric Control and Evolution of Hemoglobin.Biomolecules · 2023Review
- A retrospective on statistical mechanical models for hemoglobin allostery.The Journal of chemical physics · 2022Article
- A New Model of Hemoglobin Oxygenation.Entropy (Basel, Switzerland) · 2022Article
- Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Impact of hemoglobin biophysical studies on molecular pathogenesis and drug therapy for sickle cell disease.Molecular aspects of medicine · 2022Review
- Drug discovery by a basic research scientist.Frontiers in molecular biosciences · 2022Article
- Article
- MWC allosteric model explains unusual hemoglobin-oxygen binding curves from sickle cell drug binding.Biophysical journal · 2021Article
- Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Hemoglobin S polymerization and sickle cell disease: A retrospective on the occasion of the 70th anniversary of Pauling's Science paper.American journal of hematology · 2020Review
- Immobilization of Allantoinase for the Development of an Optical Biosensor of Oxidative Stress States.Sensors (Basel, Switzerland) · 2019Article
- Theoretical Simulation of Red Cell Sickling Upon Deoxygenation Based on the Physical Chemistry of Sickle Hemoglobin Fiber Formation.The journal of physical chemistry. B · 2018Article
- Interface Residues That Drive Allosteric Transitions Also Control the Assembly of l-Lactate Dehydrogenase.The journal of physical chemistry. B · 2018Article
- Direct observation of conformational population shifts in crystalline human hemoglobin.The Journal of biological chemistry · 2017Article
- Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Trapping quaternary structures of hemoglobin in single crystals or by encapsulation in silica gels has provided a demanding set of data to test statistical mechanical models of allostery. In this work, we compare the results of those experiments with predictions of the four major allosteric models for hemoglobin: the quaternary two-state model of Monod, Wyman, and Changeux; the tertiary two-state model of Henry et al., which is the simplest extension of the Monod-Wyman-Changeux model to include pre-equilibria of tertiary as well as quaternary conformations; the structure-based model of Szabo and Karplus; and the modification of the latter model by Lee and Karplus. We show that only the tertiary two-state model can provide a near quantitative explanation of the single-crystal and gel experimental results.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.