ArticleDental materials : official publication of the Academy of Dental Materials2015
Effect of pretreatment with collagen crosslinkers on dentin protease activity.
Article in Dental materials : official publication of the Academy of Dental Materials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 55 citations in OpenAlex.
- Article
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- A dual action approach of B-type proanthocyanidins for silencing enzymatic activity and sealing natural caries-affected dentin-resin interfaces.Journal of dentistry · 2025Article
- Use of Photoreactive Riboflavin and Blue Light Irradiation in Improving Dentin Bonding-Multifaceted Evaluation.Journal of functional biomaterials · 2025Article
- Effects of proanthocyanidin-functionalized hydroxyapatite nanoparticles on dentin bonding.Clinical oral investigations · 2024Article
- Article
- Evaluating the Effect of Sumac Extract on Dentine Micro-Hardness during pH Cycling.Journal of dentistry (Shiraz, Iran) · 2023Article
- Captopril inhibits matrix metalloproteinase activity and improves dentin bonding durability.Clinical oral investigations · 2022Article
- Antioxidants and Collagen-Crosslinking: Benefit on Bond Strength and Clinical Applicability.Materials (Basel, Switzerland) · 2020Article
- Effect of Chitosan as a Cross-Linker on Matrix Metalloproteinase Activity and Bond Stability with Different Adhesive Systems.Marine drugs · 2020Article
- Effect of silver diamine fluoride and proanthocyanidin on resistance of carious dentin to acid challenges.PloS one · 2020Article
- The inhibitory effect of carboxyl-terminated polyamidoamine dendrimers on dentine host-derived matrix metalloproteinasesRoyal Society open science · 2019Article
- High-performance therapeutic quercetin-doped adhesive for adhesive-dentin interfaces.Scientific reports · 2017Article
- Experimental primers containing synthetic and natural compounds reduce enzymatic activity at the dentin-adhesive interface under cyclic loading.Dental materials : official publication of the Academy of Dental Materials · 2016Article
- Comparative evaluation of the effect of two natural collagen cross-linkers on microtensile bond strength of self-etch adhesive system to dentin after contamination with blood and hemostatic agent: AnJournal of conservative dentistry and endodonticsArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesThis study evaluated the effect of dentin pretreatment with collagen crosslinkers on matrix metalloproteinase (MMP) and cathepsin K mediated collagen degradation.
methodsDentin beams (1mm×2mm×6mm) were demineralized in 10% H3PO4 for 24h. After baseline measurements of dry mass, beams were divided into 11 groups (n=10/group) and, were pretreated for 5min with 1% glutaraldehyde (GA); 5% GA; 1% grape-seed extract (GS); 5% GS; 10% sumac (S); 20μM curcumin (CR); 200μM CR; 0.l% riboflavin/UV (R); 0.5% R; 0.1% riboflavin-5-phosphate/UV (RP); and control (no pretreatment). After pretreatment, the beams were blot-dried and incubated in 1mL calcium and zinc-containing medium (CM, pH 7.2) at 37°C for 3, 7 or 14 days. After incubation, dry mass was reassessed and aliquots of the incubation media were analyzed for collagen C-telopeptides, ICTP and CTX using specific ELISA kits. Data were analyzed by repeated-measures ANOVA.
resultsThe rate of dry mass loss was significantly different among test groups (p<0.05). The lowest 14 day mean dry mass loss was 6.98%±1.99 in the 200μM curcumin group compared to control loss of dry mass at 32.59%±5.62, p<0.05, at 14 days. The ICTP release over the incubation period (ng/mg dry dentin) ranged between 1.8±0.51 and 31.8±1.8. CTX release from demineralized beams pretreated with crosslinkers was significantly lower than CM (5.7±0.2ng/mg dry dentin). SIGNIFICANCE: The results of this study indicate that collagen crosslinkers tested in this study are good inhibitors of cathepsin K activity in dentin. However, their inhibitory effect on MMP activity was highly variable.
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