Evidence map›Paper›PMID 26037514›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2015

Post-Gastric Bypass Hyperinsulinemic Hypoglycemia: Fructose is a Carbohydrate Which Can Be Safely Consumed.

Anne E Bantle, Qi Wang, John P Bantle

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Pramlintide for post-bariatric hypoglycaemia.Diabetes, obesity & metabolism · 2022
    Article
  3. Hypoglycemia After Gastric Bypass Surgery: Current Concepts and Controversies.The Journal of clinical endocrinology and metabolism · 2018
    Review
  4. Review
  5. Medical nutrition therapy for post-bariatric hypoglycemia: practical insights.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2017
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anne E BantleDivision of Endocrinology and Diabetes, Department of Medicine (A.E.B., J.P.B.), and Clinical and Translational Science Institute (Q.W.), University of Minnesota, Minneapolis, Minnesota 55455.
Qi WangDivision of Endocrinology and Diabetes, Department of Medicine (A.E.B., J.P.B.), and Clinical and Translational Science Institute (Q.W.), University of Minnesota, Minneapolis, Minnesota 55455.
John P BantleDivision of Endocrinology and Diabetes, Department of Medicine (A.E.B., J.P.B.), and Clinical and Translational Science Institute (Q.W.), University of Minnesota, Minneapolis, Minnesota 55455.
University of Minnesota · US

Funding

TRAINING GRANT IN DIABETES, ENDOCRINOLOGY, &METABOLISMT32DK007203 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LISA Senye CHOW, Douglas G Mashek · 1986 to 2026
$4.3M
NIDDK NIH HHS T32 DK007203
6 · The paper itself

Abstract

contextPostprandial hypoglycemia after gastric bypass surgery is a serious problem. Available treatments are often ineffective.

objectiveThe objective was to test the hypotheses that injection of rapid-acting insulin before a high-carbohydrate meal or replacement of other carbohydrates with fructose in the meal would prevent hypoglycemia.

designThis was a randomized, crossover trial comparing a high-carbohydrate meal with premeal saline injection (control), a high-carbohydrate meal with premeal insulin injection, and a high-fructose meal with total carbohydrate content similar to the control meal.

settingThe setting was an academic medical center. PATIENTS: Ten patients with post-gastric bypass hyperinsulinemic hypoglycemia participated.

interventionsInterventions included lispro insulin injected before test meals and replacement of other carbohydrates with fructose in test meals.

main outcome measureThe main outcome measure was plasma glucose < 60 mg/dL after test meals.

resultsAfter the control meal, mean peak glucose and insulin were 173 ± 47 mg/dL and 134 ± 55 mU/L, respectively; mean glucose nadir was 44 ± 15 mg/dL; and eight of 10 subjects demonstrated glucose < 60 mg/dL. Five subjects demonstrated a glucose nadir < 40 mg/dL. There were no significant differences in the corresponding values after premeal insulin treatment, except that the mean glucose nadir of 34 ± 10 mg/dL was lower (P < .05). After the fructose meal, mean peak postprandial glucose and insulin were 117 ± 20 mg/dL and 45 ± 31 mU/L, respectively (both P < .001 for comparison with control), mean glucose nadir was 67 ± 10 mg/dL (P < .001), and two of 10 subjects demonstrated glucose < 60 mg/dL (P < .05).

conclusionsPeople with post-gastric bypass hypoglycemia can consume a meal sweetened with fructose with little risk of hypoglycemia. Treatment with rapid-acting insulin before a carbohydrate-containing meal did not prevent hypoglycemia.

Indexed as

AdultBlood GlucoseCross-Over StudiesFemaleFructoseGastric BypassGastroesophageal RefluxHumansHyperinsulinismHypoglycemiaInsulinInsulin LisproMaleMealsMiddle AgedObesityBlood GlucoseFructoseInsulinInsulin Lispro

Identifiers

PMID26037514
PMCPMC5393521
OpenAlexW1786593390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.