Trial reportJournal of feline medicine and surgery2016
Use of oral trazodone for sedation in cats: a pilot study.
Trial report in Journal of feline medicine and surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 70 citations in OpenAlex.
- Pharmacokinetics, pharmacodynamics and clinical use of trazodone and its active metabolite m-chlorophenylpiperazine in the horse.Journal of veterinary pharmacology and therapeutics · 2018Trial
- Preanesthetic Administration of Trazodone Does Not Impact Anesthetic Recovery Scores in Horses.Animals : an open access journal from MDPI · 2025Article
- Effect of oral administration of trazodone on physiological and echocardiographic variables in cats.Journal of feline medicine and surgery · 2025Article
- Tools for the Approach of Fear, Anxiety, and Stress in the Domestic Feline: An Update.Veterinary medicine international · 2025Review
- Evaluation of the sedative properties of oral trazodone, gabapentin or their combination in healthy cats.Journal of feline medicine and surgery · 2024Article
- Evaluation of three doses of oral trazodone and their impact on handling, activity, and physiological parameters in rabbits: a prospective, blinded, randomized cross-over study.The Journal of veterinary medical science · 2024Article
- 2022 AAFP/ISFM Cat Friendly Veterinary Interaction Guidelines: Approach and Handling Techniques.Journal of feline medicine and surgery · 2022Article
- Description and validation of a new descriptive and multiparametric numeric rating scale to assess sedation in cats.The Canadian veterinary journal = La revue veterinaire canadienne · 2022Article
- A review of pre-appointment medications to reduce fear and anxiety in dogs and cats at veterinary visits.The Canadian veterinary journal = La revue veterinaire canadienne · 2021Review
- Feline procedural sedation and analgesia: When, why and how.Journal of feline medicine and surgery · 2020Review
- Utility of a novel activity monitor assessing physical activities and sleep quality in cats.PloS one · 2020Article
- Effects of oral trazodone on echocardiographic and hemodynamic variables in healthy cats.Journal of feline medicine and surgery · 2019Article
- Use of single-dose oral gabapentin to attenuate fear responses in cage-trap confined community cats: a double-blind, placebo-controlled field trial.Journal of feline medicine and surgery · 2018Article
- Development of a laboratory model to assess fear and anxiety in cats.Journal of feline medicine and surgery · 2017Article
- Article
- Do cats receiving pre-appointment trazodone experience less stress during veterinary visits?Veterinary evidenceReview
- Adverse effects of trazodone in dogs on primary hemostasis and electrocardiogram: A single-blinded placebo-controlled crossover study.Journal of veterinary internal medicineArticle
- Chronic dosing with mirtazapine does not produce sedation in rats.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesResistance to transportation and stressful veterinary visits are major causes for a decrease in feline veterinary care. Few options exist for oral sedatives to reduce cats' anxiety prior to veterinary visits. The purpose of this study was to evaluate the safety and efficacy of oral trazodone for use as a single dose agent for sedation in cats.
methodsSix laboratory cats were given single 50, 75 and 100 mg doses of trazodone and placebo. Trazodone 100 mg and placebo treatments were randomized. Pre- and post-study laboratory values and physical examinations were compared. During each 4 h period post-treatment, sedation was measured via accelerometers and video observations scored by an observer blinded to treatment. Examinations were performed on the cats 90 mins after treatment, and their behavioral responses scored by the same blinded observer.
resultsNo adverse effects or changes in physical examinations or laboratory values were detected as a result of trazodone administration. Accelerometer data showed trazodone 50, 75 and 100 mg caused sedation as measured by activity reduction (83%, 46% and 66%, respectively). In contrast, there was a 14% activity increase after placebo. There was a significant reduction in video observation scores when cats were given trazodone 100 mg compared with placebo. Mean latency to peak sedation for trazodone 100 mg occurred at 2 h. Scores for behavioral response to examination, performed at 90 mins post-treatment, were not significantly different between cats receiving trazodone 100 mg and placebo. CONCLUSIONS AND RELEVANCE: Trazodone was well tolerated in this population of cats and caused appreciable sedation at all doses. Behavior during examination was not significantly different when cats received trazodone 100 mg compared with placebo. Further studies are recommended to investigate the use of oral trazodone in cats for the purpose of decreasing anxiety assocaited with transportation and examination.
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