ArticleNature communications2015
CUL4 forms an E3 ligase with COP1 and SPA to promote light-induced degradation of PIF1.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
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Who cites it
71 citing papers in PubMed, 124 citations in OpenAlex.
- CML20 integrates phytochrome and calcium signaling pathways to optimize seed germination under abiotic stress.Nature communications · 2026Article
- Light-Controlled Seed Germination: Molecular Integration With Environmental Signals.Plant, cell & environment · 2026Review
- Twenty-five years of photobodies: formation, composition, and the 2-compartment logic of phytochrome B signaling.Plant physiology · 2026Review
- Holistic overview of regulatory networks governing seed dormancy and germination in plants.Science China. Life sciences · 2026Review
- Beyond HY5: COP1 Posttranslational Control of Anthocyanin Biosynthesis Proteins in Horticultural Crops.Plants (Basel, Switzerland) · 2026Review
- Tailored UV-A Irradiation and Callus Selection Enable Distinct Flavonoid Profile Production in Grape Cell Cultures.Foods (Basel, Switzerland) · 2026Article
- Translating research on seed dormancy and germination from Arabidopsis to temperate cereals to control pre-harvest sprouting.Frontiers in plant science · 2026Review
- Regulatory and retrograde signaling networks in the chlorophyll biosynthetic pathway.Journal of integrative plant biology · 2025Review
- Making the most of canopy light: shade avoidance under a fluctuating spectrum and irradiance.Journal of experimental botany · 2025Review
- NPR1 promotes blue light-induced plant photomorphogenesis by ubiquitinating and degrading PIF4.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- PHOSPHATASE 2A dephosphorylates PHYTOCHROME-INTERACTING FACTOR3 to modulate photomorphogenesis in Arabidopsis.The Plant cell · 2024Article
- The lowdown on breakdown: Open questions in plant proteolysis.The Plant cell · 2024Review
- How Histone Acetyltransferases Shape Plant Photomorphogenesis and UV Response.International journal of molecular sciences · 2024Review
- What is going on inside of phytochrome B photobodies?The Plant cell · 2024Review
- Light signaling in plants-a selective history.Plant physiology · 2024Review
- Photobody formation spatially segregates two opposing phytochrome B signaling actions of PIF5 degradation and stabilization.Nature communications · 2024Article
- The phosphorylation of carboxyl-terminal eIF2α by SPA kinases contributes to enhanced translation efficiency during photomorphogenesis.Nature communications · 2024Article
- HOS15 represses flowering by promoting GIGANTEA degradation in response to low temperature in Arabidopsis.Plant communications · 2023Article
- Article
- Population Structure, Genetic Diversity and Candidate Genes for the Adaptation to Environmental Stress inPlants (Basel, Switzerland) · 2023Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Plants undergo contrasting developmental programs in dark and light. Photomorphogenesis, a light-adapted programme is repressed in the dark by the synergistic actions of CUL4(COP1-SPA) E3 ubiquitin ligase and a subset of basic helix-loop-helix transcription factors called phytochrome interacting factors (PIFs). To promote photomorphogenesis, light activates the phytochrome family of sensory photoreceptors, which inhibits these repressors by poorly understood mechanisms. Here, we show that the CUL4(COP1-SPA) E3 ubiquitin ligase is necessary for the light-induced degradation of PIF1 in Arabidopsis. The light-induced ubiquitylation and subsequent degradation of PIF1 is reduced in the cop1, spaQ and cul4 backgrounds. COP1, SPA1 and CUL4 preferentially form complexes with the phosphorylated forms of PIF1 in response to light. The cop1 and spaQ seeds display strong hyposensitive response to far-red light-mediated seed germination and light-regulated gene expression. These data show a mechanism by which an E3 ligase attenuates its activity by degrading its cofactor in response to light.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.