ArticleReproductive sciences (Thousand Oaks, Calif.)2015
Progesterone Metabolites Produced by Cytochrome P450 3A Modulate Uterine Contractility in a Murine Model.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- DInternational journal of molecular sciences · 2026Article
- What now? A critical evaluation of over 20 years of clinical and research experience with 17-alpha hydroxyprogesterone caproate for recurrent preterm birth prevention.American journal of obstetrics & gynecology MFM · 2023Review
- Progesterone Suppresses Uterine Contraction by Reducing OdontogenicBiomolecules · 2022Article
- Progesterone: A Steroid with Wide Range of Effects in Physiology as Well as Human Medicine.International journal of molecular sciences · 2022Review
- Secretory products of the corpus luteum and preeclampsia.Human reproduction update · 2021Review
- Hormonal activity in commonly used Black hair care products: evaluating hormone disruption as a plausible contribution to health disparities.Journal of exposure science & environmental epidemiology · 2021Article
- Alterations in endogenous progesterone metabolism associated with spontaneous very preterm delivery.Human reproduction open · 2020Article
- Translational Systems Pharmacology Studies in Pregnant Women.CPT: pharmacometrics & systems pharmacology · 2018Review
- Profile of MicroRNA Expression in Endometrial Cell duringTissue engineering and regenerative medicine · 2017Article
- Characterization of Maternal and Fetal CYP3A-Mediated Progesterone Metabolism.Fetal and pediatric pathology · 2017Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveWe seek to characterize the effect of progesterone metabolites on spontaneous and oxytocin-induced uterine contractility. STUDY
designSpontaneous contractility was studied in mouse uterine horns after treatment with progesterone, 2α-hydroxyprogesterone, 6β-hydroxyprogesterone (6β-OHP), 16α-hydroxyprogesterone (16α-OHP), or 17-hydroxyprogesterone caproate (17-OHPC) at 10(-9) to 10(-6) mol/L. Uterine horns were exposed to progestins (10(-6) mol/L), followed by increasing concentrations of oxytocin (1-100 nmol/L) to study oxytocin-induced contractility. Contraction parameters were compared for each progestin and matched vehicle control using repeated measures 2-way analysis of variance. In vitro metabolism of progesterone by recombinant cytochrome P450 3A (CYP3A) microsomes (3A5, 3A5, and 3A7) identified major metabolites.
resultsOxytocin-induced contractile frequency was decreased by 16α-OHP (P = .03) and increased by 6β-OHP (P = .05). Progesterone and 17-OHPC decreased oxytocin-induced contractile force (P = .02 and P = .04, respectively) and frequency (P = .02 and P = .03, respectively). Only progesterone decreased spontaneous contractile force (P = .02). Production of 16α-OHP and 6β-OHP metabolites were confirmed in all CYP3A isoforms tested.
conclusionProgesterone metabolites produced by maternal or fetal CYP3A enzymes influence uterine contractility.
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Registered trials
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