ArticleJournal of oral microbiology2015
The oral mucosal and salivary microbial community of Behçet's syndrome and recurrent aphthous stomatitis.
Article in Journal of oral microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- Systematic review and meta-analysis of oxidative stress and antioxidant markers in recurrent aphthous stomatitis.BMC oral health · 2023Pooled it
- Comparison of the efficacy of placental extract gel vs. curcumin gel in the treatment of oral aphthous ulcer: a randomized clinical trial.Frontiers in dental medicine · 2026Trial
- The Role of Viral and Bacterial Infections in the Etiology of Behçet's Disease.Journal of clinical laboratory analysis · 2026Review
- Functional and taxonomic dysbiosis of the supragingival plaque metagenome in Behçet's disease.Journal of oral microbiology · 2025Article
- The Possible Genetic and Environmental Factors Related to Behçet's Disease: Trisomy 8 and SARS-CoV-2.Internal medicine (Tokyo, Japan) · 2025Article
- Comparative analysis of oral microbiome in saliva samples of oral leukoplakia, proliferative leukoplakia and oral squamous cell carcinoma.Frontiers in oral health · 2025Article
- Possible Association between Behçet's Disease and Periodontal diseases.BMC oral health · 2024Article
- Can the mucosal attacks of Behçet's disease be predicted?Archives of dermatological research · 2024Article
- Association of cigarette smoking with oral bacterial microbiota and cardiometabolic health in Chinese adults.BMC microbiology · 2023Article
- Heat Shock Proteins in Behçet SyndromeBalkan medical journal · 2023Review
- How Do Microorganisms Influence the Development of Endometriosis? Participation of Genital, Intestinal and Oral Microbiota in Metabolic Regulation and Immunopathogenesis of Endometriosis.International journal of molecular sciences · 2023Review
- Treatment Options in Pediatric Behçet's Disease.Paediatric drugs · 2023Review
- Innate immune responses in Behçet disease and relapsing polychondritis.Frontiers in medicine · 2023Review
- Low density neutrophils are increased in patients with Behçet's disease but do not explain differences in neutrophil function.Journal of inflammation (London, England) · 2022Article
- Review
- Detection and Analysis of the Oral Flora in Patients with Recurrent Aphthous Stomatitis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Alteration of the Fecal but Not Salivary Microbiome in Patients with Behçet's Disease According to Disease Activity Shift.Microorganisms · 2021Article
- Article
- Behçet's Disease-Do Microbiomes and Genetics Collaborate in Pathogenesis?Frontiers in immunology · 2021Review
- Oral Health and Its Aetiological Role in Behçet's Disease.Frontiers in medicine · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBehçet's syndrome (BS) is a multisystem immune-related disease of unknown etiology. Recurrent aphthous stomatitis (RAS) is characterized by the presence of idiopathic oral ulceration without extraoral manifestation. The interplay between the oral microbial communities and the immune response could play an important role in the etiology and pathogenesis of both BS and RAS.
objectiveTo investigate the salivary and oral mucosal microbial communities in BS and RAS.
methodsPurified microbial DNA isolated from saliva samples (54 BS, 25 healthy controls [HC], and 8 RAS) were examined by the human oral microbe identification microarray. Cultivable salivary and oral mucosal microbial communities from ulcer and non-ulcer sites were identified by matrix-assisted laser desorption/ionization time-of-flight analysis. Mycobacterium spp. were detected in saliva and in ulcer and non-ulcer oral mucosal brush biopsies following culture on Lowenstein-Jensen slopes and Mycobacterial Growth Indicator Tubes.
resultsThere was increased colonization with Rothia denticariosa of the non-ulcer sites of BS and RAS patients (p<0.05). Ulcer sites in BS were highly colonized with Streptococcus salivarius compared to those of RAS (p<0.05), and with Streptococcus sanguinis compared to HC (p<0.0001). Oral mucosa of HC were more highly colonized with Neisseria and Veillonella compared to all studied groups (p<0.0001).
conclusionsDespite the uncertainty whether the reported differences in the oral mucosal microbial community of BS and RAS are of causative or reactive nature, it is envisaged that restoring the balance of the oral microbial community of the ulcer sites may be used in the future as a new treatment modality for oral ulceration.
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