ArticleHuman brain mapping2015
Rich club analysis in the Alzheimer's disease connectome reveals a relatively undisturbed structural core network.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed, 141 citations in OpenAlex.
- Modular brain networks shape amyloid-driven tau spread and cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Critical and non-critical connections not differently associated with either Alzheimer's disease or vascular pathologies.medRxiv : the preprint server for health sciences · 2026Article
- Harmonized connectome resampling for variance in voxel sizes.Magnetic resonance imaging · 2025Article
- Quantitative susceptibility mapping for Alzheimer's disease, mild cognitive impairment, and normal aging: evaluation of corpus callosum.Quantitative imaging in medicine and surgery · 2025Article
- Network analysis of cognition and function in Alzheimer's disease: a cross-sectional study.Frontiers in psychiatry · 2025Article
- Disruption of global brain network topology in amnestic MCI: evidence from multimodal DTI and fMRI.Frontiers in neuroscience · 2025Article
- Overview of ADNI MRI.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Voxel-Wise Fusion of 3T and 7T Diffusion MRI Data to Extract more Accurate Fiber Orientations.Brain topography · 2024Article
- The brain network hub degeneration in Alzheimer's disease.Biophysics reports · 2024Article
- The characteristic patterns of individual brain susceptibility networks underlie Alzheimer's disease and white matter hyperintensity-related cognitive impairment.Translational psychiatry · 2024Article
- Disrupted pattern of rich-club organization in structural brain network from prediabetes to diabetes: A population-based study.Human brain mapping · 2024Article
- Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer's disease.Network neuroscience (Cambridge, Mass.) · 2024Article
- Reorganized brain functional network topology in stable and progressive mild cognitive impairment.Frontiers in aging neuroscience · 2024Article
- Relationship between topological efficiency of white matter structural connectome and plasma biomarkers across the Alzheimer's disease continuum.Human brain mapping · 2024Article
- Altered topological structure of the brain white matter in maltreated children through topological data analysis.Network neuroscience (Cambridge, Mass.) · 2024Article
- Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer disease.bioRxiv : the preprint server for biology · 2023Article
- Altered structural connectome of children with auditory processing disorder: a diffusion MRI study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Review
- An eXplainability Artificial Intelligence approach to brain connectivity in Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- The Adult Neurogenesis Theory of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 1 country.
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Abstract
Diffusion imaging can assess the white matter connections within the brain, revealing how neural pathways break down in Alzheimer's disease (AD). We analyzed 3-Tesla whole-brain diffusion-weighted images from 202 participants scanned by the Alzheimer's Disease Neuroimaging Initiative-50 healthy controls, 110 with mild cognitive impairment (MCI) and 42 AD patients. From whole-brain tractography, we reconstructed structural brain connectivity networks to map connections between cortical regions. We tested whether AD disrupts the "rich club" - a network property where high-degree network nodes are more interconnected than expected by chance. We calculated the rich club properties at a range of degree thresholds, as well as other network topology measures including global degree, clustering coefficient, path length, and efficiency. Network disruptions predominated in the low-degree regions of the connectome in patients, relative to controls. The other metrics also showed alterations, suggesting a distinctive pattern of disruption in AD, less pronounced in MCI, targeting global brain connectivity, and focusing on more remotely connected nodes rather than the central core of the network. AD involves severely reduced structural connectivity; our step-wise rich club coefficients analyze points to disruptions predominantly in the peripheral network components; other modalities of data are needed to know if this indicates impaired communication among non rich club regions. The highly connected core was relatively preserved, offering new evidence on the neural basis of progressive risk for cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.