Evidence map›Paper›PMID 26037114›Full record

ArticleJournal of neurovirology2015

Chronic SIV and morphine treatment increases heat shock protein 5 expression at the synapse.

Gurudutt Pendyala, Palsamy Periyasamy, Shannon Callen, Howard S Fox, Steven J Lisco, Shilpa J Buch

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Neurobehavioral Characterization of Perinatal Oxycodone-Exposed Offspring in Early Adolescence.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024
    Article
  2. Article
  3. Opioid and neuroHIV Comorbidity - Current and Future Perspectives.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  4. Article
  5. Epigenetic Promoter DNA Methylation of miR-124 Promotes HIV-1 Tat-Mediated Microglial Activation via MECP2-STAT3 Axis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Gurudutt PendyalaDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, USA.
Palsamy PeriyasamyDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE, 68198, USA.
Shannon CallenDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE, 68198, USA.
Howard S FoxDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE, 68198, USA.
Steven J LiscoDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, USA.
Shilpa J BuchDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE, 68198, USA. sbuch@unmc.edu.
University of Nebraska Medical Center · US

Funding

Therapeutics Core (Page 286)P30MH062261 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E · 2000 to 2021
$37.7M
Morphine and the Neuropathogenesis of SIV in MacaquesR01DA024442 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BUCH, SHILPA J. · 2007 to 2011
$2.8M
HIV-Encephalitis and Cocaine Abuse: Mechanism of Synergy and TherapyR01DA020392 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BUCH, SHILPA J. · 2006 to 2010
$1.4M
PLGA/Antisense IL-10: Gene Therapy for Cocaine Abusers with HADR21DA023397 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BUCH, SHILPA J. · 2009 to 2010
$423k
NIDA NIH HHS DA020392NIDA NIH HHS DA023397NIDA NIH HHS DA024442NIDA NIH HHS R01 DA020392NIDA NIH HHS R01 DA024442NIDA NIH HHS R21 DA023397NIMH NIH HHS P30 MH062261
6 · The paper itself

Abstract

The abuse of opiates such as morphine in synergy with HIV infection accelerates neurocognitive impairments and neuropathology in the CNS of HIV-infected subjects, collectively referred to as HAND. To identify potential pathogenic markers associated with HIV and morphine in perturbing the synaptic architecture, we performed quantitative mass spectrometry proteomics on purified synaptosomes isolated from the caudate of two groups of rhesus macaques chronically infected with SIV differing by one regimen-morphine treatment. The upregulation of heat shock 70-kDa protein 5 in the SIV + morphine group points to increased cellular stress during SIV/morphine interaction thus leading to CNS dysfunction.

Indexed as

Analgesics, OpioidAnimalsBlotting, WesternCell LineEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsHumansMacaca mulattaMorphineNeuronsProteomicsReal-Time Polymerase Chain ReactionSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationSynapsesAnalgesics, OpioidEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsHSPA5 protein, humanMorphineCNSHSPA5MorphineProteomicsSIVSynaptosomes

Identifiers

PMID26037114
PMCPMC4618049
OpenAlexW655928414

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.