ArticleJournal of the American Heart Association2015
Age and sex differences in long-term outcomes following implantable cardioverter-defibrillator placement in contemporary clinical practice: findings from the Cardiovascular Research Network.
Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Predictors of mortality and ICD shock therapy in primary prophylactic ICD patients-A systematic review and meta-analysis.PloS one · 2017Pooled it
- Pooled it
- Impact of sex on the utilization of defibrillation-capable cardiac implantable devices and outcome: results from the German device registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Smoking status and the association between patient-level factors and survival among lung cancer patients.Journal of the National Cancer Institute · 2023Article
- Development and external validation of prognostic models to predict sudden and pump-failure death in patients with HFrEF from PARADIGM-HF and ATMOSPHERE.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Article
- Sex differences in Cardiac electronic device implantation: Outcomes from an Australian multi-centre clinical quality registry.International journal of cardiology. Heart & vasculature · 2021Article
- Research Needs and Priorities for Catheter Ablation of Atrial Fibrillation: A Report From a National Heart, Lung, and Blood Institute Virtual Workshop.Circulation · 2020Article
- Sex Differences in the Management of Advanced Heart Failure.Current treatment options in cardiovascular medicine · 2018Review
- Cardiac implantable electrical devices in women.Clinical cardiology · 2018Review
- [ICD in elderly patients].Herzschrittmachertherapie & Elektrophysiologie · 2017Review
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
backgroundPatient sex and age may influence rates of death after receiving an implantable cardioverter-defibrillator for primary prevention. Differences in outcomes other than mortality and whether these differences vary by heart failure symptoms, etiology, and left ventricular ejection fraction are not well characterized. METHODS AND
resultsWe studied 2954 patients with left ventricular ejection fraction ≤0.35 undergoing first-time implantable cardioverter-defibrillator for primary prevention within the Cardiovascular Research Network; 769 patients (26%) were women, and 2827 (62%) were aged >65 years. In a median follow-up of 2.4 years, outcome rates per 1000 patient-years were 109 for death, 438 for hospitalization, and 111 for heart failure hospitalizations. Procedure-related complications occurred in 8.36%. In multivariable models, women had significantly lower risks of death (hazard ratio 0.67, 95% CI 0.56 to 0.80) and heart failure hospitalization (hazard ratio 0.82, 95% CI 0.68 to 0.98) and higher risks for complications (hazard ratio 1.38, 95% CI 1.01 to 1.90) than men; patients aged >65 years had higher risks of death (hazard ratio 1.55, 95% CI 1.30 to 1.86) and heart failure hospitalization (hazard ratio 1.25, 95% CI 1.05 to 1.49) than younger patients. Age and sex differences were generally consistent in strata according to symptoms, etiology, and severity of left ventricular systolic dysfunction, except the higher risk of complications in women, which differed by New York Heart Association classification (P=0.03 for sex-New York Heart Association interaction), and the risk of heart failure hospitalization in older patients, which differed by etiology of heart failure (P=0.05 for age-etiology interaction).
conclusionsThe burden of adverse outcomes after receipt of an implantable cardioverter-defibrillator for primary prevention is substantial and varies according to patient age and sex. These differences in outcome generally do not vary according to baseline heart failure characteristics.
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