ArticleEnvironmental health and preventive medicine2015
The relationship between body mass index and uric acid: a study on Japanese adult twins.
Article in Environmental health and preventive medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed, 86 citations in OpenAlex.
- The gut microbiome drives inter- and intra-individual differences in metabolism of bioactive small molecules.Scientific reports · 2020Trial
- Sodium-Glucose Cotransporter-2 Inhibitor Immediately Decreases Serum Uric Acid Levels in Type 2 Diabetic Patients.Medical science monitor : international medical journal of experimental and clinical research · 2020Trial
- Deciphering the association between uric acid and kidney stones: insights into the mediating roles of BMI and serum iron: a cross-sectional study based on NHANES 2007-2018.International journal of surgery (London, England) · 2026Article
- Uric acid, vitamin D, and left ventricular hypertrophy: Unveiling cardiovascular risks - a retrospective cross-sectional study.Medicine · 2026Article
- Serum uric acid and its association with intrauterine insemination outcomes in women with polycystic ovarian syndrome.The Indian journal of medical research · 2026Article
- Association between normal-weight central obesity and asymptomatic hyperuricemia in Korean adults: a cross-sectional study.BMC public health · 2025Article
- Inverse association of dietary consumption of n3 and n6 fatty acids with hyperuricemia among adults.PloS one · 2025Article
- Association of obesity with hyperuricaemia among HIV-positive patients on antiretroviral therapy in South-Western Uganda.African journal of laboratory medicine · 2025Article
- Nonlinear association of cardiometabolic index with hyperuricemia: insights from the NHANES 1999-2018 study.Frontiers in endocrinology · 2025Article
- A combined association of obesity, alanine aminotransferase and creatinine with hyperuricemia in youth aged 13-20 years.Frontiers in nutrition · 2024Article
- Sex-specific differences in the associations between adiposity indices and incident hyperuricemia among middle-aged and older adults: a nationwide longitudinal study.Frontiers in endocrinology · 2024Article
- The association of visceral fat metabolism score with hyperuricemia-evidence from NHANES 1999-2018.Frontiers in nutrition · 2024Article
- Sex Difference in the Associations among Obesity-Related Indices with Hyperuricemia in a Large Taiwanese Population Study.Nutrients · 2023Article
- Serum Urate Levels and Ultrasound Characteristics of Carotid Atherosclerosis across Obesity Phenotypes.Biomedicines · 2023Article
- Association between the Weight-Adjusted Waist Index and Serum Uric Acid: A Cross-Sectional Study.International journal of clinical practice · 2023Article
- Prevalence of Obesity in Newly Onset Diabetes Mellitus and Its Relationship with Uric Acid: An Indian Cross-Sectional Study.International journal of general medicine · 2023Article
- Serum uric acid level predicts the progression of amyotrophic lateral sclerosis following treatment with edaravone.Redox report : communications in free radical research · 2022Article
- Obese female mice do not exhibit overt hyperuricemia despite hepatic steatosis and impaired glucose tolerance.Advances in redox research · 2022Article
- Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Association Between Total Percent Fat and Serum Uric Acid in Adults.Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe present study aimed to investigate the association between body mass index (BMI) and uric acid (UA) using the twin study methodology to adjust for genetic factors.
methodsThe association between BMI and UA was investigated in a cross-sectional study using data from both monozygotic and dizygotic twins registered at the Osaka University Center for Twin Research and the Osaka University Graduate School of Medicine. From January 2011 to March 2014, 422 individuals participated in the health examination. We measured height, weight, age, BMI, lifestyle habits (Breslow's Health Practice Index), serum UA, and serum creatinine. To investigate the association between UA and BMI with adjustment for the clustering of a twin within a pair, individual-level analyses were performed using generalized linear mixed models (GLMMs). To investigate an association with adjustment for genetic and family environmental factors, twin-pair difference values analyses were performed.
resultsIn all analysis, BMI was associated with UA in men and women. Using the GLMMs, standardized regression coefficients were 0.194 (95 % confidence interval: 0.016-0.373) in men and 0.186 (95 % confidence interval: 0.071-0.302) in women. Considering twin-pair difference value analyses, standardized regression coefficients were 0.333 (95 % confidence interval: 0.072-0.594) in men and 0.314 (95 % confidence interval: 0.151-0.477) in women.
conclusionsThe present study shows that BMI was significantly associated with UA, after adjusting for both genetic and familial environment factors in both men and women.
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