ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2015
Parkinson's disease-related spatial covariance pattern identified with resting-state functional MRI.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Functional brain changes in Parkinson's disease: a whole brain ALE study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Resting-state functional reorganization in Parkinson's disease: An activation likelihood estimation meta-analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2017Pooled it
- Combined Diffusion Tensor Imaging and Arterial Spin Labeling as Markers of Early Parkinson's disease.Scientific reports · 2016Trial
- Emerging insight in genetics and therapies in young-onset Parkinson's disease (YOPD): a comprehensive review.Journal of neurology · 2026Review
- Comparison of spontaneous brain activity in distinguishing parkinsonian variant of multiple system atrophy from Parkinson's disease at an early stage.Frontiers in aging neuroscience · 2024Article
- Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment.GeroScience · 2022Article
- Gray Matter Network Associated With Attention in Children With Attention Deficit Hyperactivity Disorder.Frontiers in psychiatry · 2022Article
- The role of neuroimaging in Parkinson's disease.Journal of neurochemistry · 2021Review
- Parkinson's disease-related pattern (PDRP) identified using resting-state functional MRI: Validation study.Neuroimage. Reports · 2021Article
- The Cerebellum Is a Common Key for Visuospatial Execution and Attention in Parkinson's Disease.Diagnostics (Basel, Switzerland) · 2021Article
- Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders.Bioelectronic medicine · 2021Review
- Dynamic Network Connectivity Reveals Markers of Response to Deep Brain Stimulation in Parkinson's Disease.Frontiers in human neuroscience · 2021Article
- Amble Gait EEG Points at Complementary Cortical Networks Underlying Stereotypic Multi-Limb Co-ordination.Frontiers in human neuroscience · 2021Article
- Clinically relevant connectivity features define three subtypes of Parkinson's disease patients.Human brain mapping · 2020Article
- Cerebellar functional abnormalities in early stage drug-naïve and medicated Parkinson's disease.Journal of neurology · 2019Article
- Abnormal Spontaneous Brain Activity in Early Parkinson's Disease With Mild Cognitive Impairment: A Resting-State fMRI Study.Frontiers in physiology · 2018Article
- Resting-state connectivity in neurodegenerative disorders: Is there potential for an imaging biomarker?NeuroImage. Clinical · 2018Review
- Intra- and Inter-scanner Reliability of Scaled Subprofile Model of Principal Component Analysis on ALFF in Resting-State fMRI Under Eyes Open and Closed Conditions.Frontiers in neuroscience · 2018Article
- Magnetic resonance imaging for the diagnosis of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2017Review
- Brain Magnetic Resonance Imaging (MRI) as a Potential Biomarker for Parkinson's Disease (PD).Brain sciences · 2017Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
In this study, we sought to identify a disease-related spatial covariance pattern of spontaneous neural activity in Parkinson's disease using resting-state functional magnetic resonance imaging (MRI). Time-series data were acquired in 58 patients with early to moderate stage Parkinson's disease and 54 healthy controls, and analyzed by Scaled Subprofile Model Principal Component Analysis toolbox. A split-sample analysis was also performed in a derivation sample of 28 patients and 28 control subjects and validated in a prospective testing sample of 30 patients and 26 control subjects. The topographic pattern of neural activity in Parkinson's disease was characterized by decreased activity in the striatum, supplementary motor area, middle frontal gyrus, and occipital cortex, and increased activity in the thalamus, cerebellum, precuneus, superior parietal lobule, and temporal cortex. Pattern expression was elevated in the patients compared with the controls, with a high accuracy (90%) to discriminate the patients from the controls. The split-sample analysis produced a similar pattern but with a lower accuracy for group discrimination in both the derivation (80%) and the validation (73%) samples. Our results showed that resting-state functional MRI can be potentially useful for identification of Parkinson's disease-related spatial covariance patterns, and for differentiation of Parkinson's disease patients from healthy controls at an individual level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.