ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2015
Hippocampal complex atrophy in poststroke and mild cognitive impairment.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Predicting Long-Term Cognitive Impairments in Survivors after Cardiac Arrest: A Systematic Review.Journal of rehabilitation medicine · 2023Pooled it
- Post-Stroke Working Memory Dysfunction: A Meta-Analysis and Systematic Review.Neuropsychology review · 2021Pooled it
- Association between total-Tau and brain atrophy one year after first-ever stroke.BMC neurology · 2017Trial
- Unravelling the nexus of stroke and dementia: Deciphering the role of secondary neurodegeneration in orchestrating cognitive decline.Neuroprotection (Chichester, England) · 2025Review
- The neuroimaging of neurodegenerative and vascular disease in the secondary prevention of cognitive decline.Neural regeneration research · 2021Article
- Hippocampal atrophy and cognitive function in transient ischemic attack and minor stroke patients over three years.Cerebral circulation - cognition and behavior · 2021Article
- Growth Hormone Treatment Promotes Remote Hippocampal Plasticity after Experimental Cortical Stroke.International journal of molecular sciences · 2020Article
- No evidence for amyloid pathology as a key mediator of neurodegeneration post-stroke - a seven-year follow-up study.BMC neurology · 2020Article
- Ongoing Secondary Degeneration of the Limbic System in Patients With Ischemic Stroke: A Longitudinal MRI Study.Frontiers in neurology · 2019Article
- [18F]-Flutemetamol Uptake in Cortex and White Matter: Comparison with Cerebrospinal Fluid Biomarkers and [18F]-Fludeoxyglucose.Journal of Alzheimer's disease : JAD · 2018Article
- Impaired synaptic function is linked to cognition in Parkinson's disease.Annals of clinical and translational neurology · 2017Article
- Improved Automatic Segmentation of White Matter Hyperintensities in MRI Based on Multilevel Lesion Features.Neuroinformatics · 2017Article
- White matter hyperintensity microstructure in amyloid dysmetabolism.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate putative interacting or distinct pathways for hippocampal complex substructure (HCS) atrophy and cognitive affection in early-stage Alzheimer's disease (AD) and cerebrovascular disease (CVD), we recruited healthy controls, patients with mild cognitive impairment (MCI) and poststroke patients. HCSs were segmented, and quantitative white-matter hyperintensity (WMH) load and cerebrospinal fluid (CSF) amyloid-β concentrations were determined. The WMH load was higher poststroke. All examined HCSs were smaller in amyloid-positive MCI than in controls, and the subicular regions were smaller poststroke. Memory was reduced in amyloid-positive MCI, and psychomotor speed and executive function were reduced in poststroke and amyloid-positive MCI. Size of several HCS correlated with WMH load poststroke and with CSF amyloid-β concentrations in MCI. In poststroke and amyloid-positive MCI, neuropsychological function correlated with WMH load and hippocampal volume. There are similar patterns of HCS atrophy in CVD and early-stage AD, but different HCS associations with WMH and CSF biomarkers. WMHs add to hippocampal atrophy and the archetypal AD deficit delayed recall. In line with mounting evidence of a mechanistic link between primary AD pathology and CVD, these additive effects suggest interacting pathologic processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.