ArticleStem cell research & therapy2015
Characterization of bursa subacromialis-derived mesenchymal stem cells.
Article in Stem cell research & therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 84 citations in OpenAlex.
- Subacromial bursa augmentation in arthroscopic rotator cuff repair: Clinical and doppler ultrasound assessment-A preliminary study.Journal of experimental orthopaedics · 2026Article
- Removal or retention: evolving views on possible roles of the subacromial bursa in rotator cuff disease.EFORT open reviews · 2025Review
- Combined Subacromial Bursal Stem Cell Therapy and Platelet-Rich Plasma Alongside Arthroscopic Rotator Cuff Surgery Reduces Postoperative Pain and Improves Functional Outcomes: A Retrospective Study.Journal of clinical medicine · 2025Article
- Biologically Enhanced Repair of Interstitial Rotator Cuff Tears With Intralesional Platelet-Rich Plasma and Bursal Tissue Injection.Arthroscopy techniques · 2025Article
- Mini-open transosseous repair with bursal augmentation improves outcomes in massive rotator cuff tears.Scientific reports · 2025Article
- The subacromial bursa modulates tendon healing after rotator cuff injury in rats.Science translational medicine · 2024Article
- Human Rotator Cuff Tears Reveal an Age-Dependent Increase in Markers of Cellular Senescence and Selective Removal of Senescent Cells With Dasatinib + Quercetin Increases Genetic Expression of COL1A1 In Vitro.Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2024Article
- Article
- The effect of augmenting suture material with magnesium and platelet-rich plasma on theJSES international · 2023Article
- Arthroscopic Rotator Cuff Repair with a Fibrin Scaffold Containing Growth Factors and Autologous Progenitor Cells Derived From Humeral cBMA Improves Clinical Outcomes in High Risk Patients.Arthroscopy, sports medicine, and rehabilitation · 2022Article
- Tendon healing: a concise review on cellular and molecular mechanisms with a particular focus on the Achilles tendon.Bone & joint research · 2022Article
- Research perspectives-Pipelines to human tendon transcriptomics.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Review
- Efficacy of Arthroscopic Shavers for the Retrieval and Processing of Connective Tissue Progenitor Cells from Subacromial Bursal Tissue.Journal of clinical medicine · 2022Article
- Review
- Trochanteric Bursa Is a Source of Connective Tissue Progenitor Cells.Arthroscopy, sports medicine, and rehabilitation · 2021Article
- Augmenting Suture Tape Used in Rotator Cuff Surgery With Magnesium Increases in Vitro Cellular Adhesion of Human Subacromial Bursal Tissue.Arthroscopy, sports medicine, and rehabilitation · 2021Article
- Histological and molecular features of the subacromial bursa of rotator cuff tears compared to non-tendon defects: a pilot study.BMC musculoskeletal disorders · 2021Article
- Analysis of Patient Factors Affecting In Vitro Characteristics of Subacromial Bursal Connective Tissue Progenitor Cells during Rotator Cuff Repair.Journal of clinical medicine · 2021Article
- Arthroscopic Rotator Cuff Repair Augmented with Autologous Subacromial Bursa Tissue, Concentrated Bone Marrow Aspirate, Platelet-Rich Plasma, Platelet-Poor Plasma, and Bovine Thrombin.Arthroscopy techniques · 2021Article
- Decreased Colony-Forming Ability of Subacromial Bursa-Derived Cells During Revision Arthroscopic Rotator Cuff Repair.Arthroscopy, sports medicine, and rehabilitation · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe bursa subacromialis (BS) provides the gliding mechanism of the shoulder and regenerates itself after surgical removal. Therefore, we explored the presence of mesenchymal stem cells (MSCs) within the human adult BS tissue and characterized the BS cells compared to MSCs from bone marrow (BMSCs) on a molecular level.
methodsBS cells were isolated by collagenase digest from BS tissues derived from patients with degenerative rotator cuff tears, and BMSCs were recovered by adherent culture from bone-marrow of patients with osteoarthritis of the hip. BS cells and BMSCs were compared upon their potential to proliferate and differentiate along chondrogenic, osteogenic and adipogenic lineages under specific culture conditions. Expression profiles of markers associated with mesenchymal phenotypes were comparatively evaluated by flow cytometry, immunohistochemistry, and whole genome array analyses.
resultsBS cells and BMSCs appeared mainly fibroblastic and revealed almost similar surface antigen expression profiles, which was CD44(+), CD73(+), CD90(+), CD105(+), CD106(+), STRO-1(+), CD14(-), CD31(-), CD34(-), CD45(-), CD144(-). Array analyses revealed 1969 genes upregulated and 1184 genes downregulated in BS cells vs. BMSCs, indicating a high level of transcriptome similarity. After 3 weeks of differentiation culture, BS cells and BMSCs showed a similar strong chondrogenic, adipogenic and osteogenic potential, as shown by histological, immunohistochemical and RT-PCR analyses in contrast to the respective negative controls.
conclusionsOur in vitro characterizations show that BS cells fulfill all characteristics of mesenchymal stem cells, and therefore merit further attention for the development of improved therapies for various shoulder pathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.