Evidence map›Paper›PMID 26035703›Full record

ArticleBritish journal of cancer2015

Evaluation of serum CEA, CYFRA21-1 and CA125 for the early detection of colorectal cancer using longitudinal preclinical samples.

D S Thomas, E-O Fourkala, S Apostolidou, R Gunu, A Ryan, I Jacobs, U Menon, W Alderton, A Gentry-Maharaj, J F Timms

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 3 syntheses or guidelines pooled it, 131 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. A 5-Hydroxymethylcytosine-Based Noninvasive Model for Early Detection of Colorectal Carcinomas and Advanced Adenomas: The METHOD-2 Study.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Observational
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

D S ThomasWomen's Cancer, Institute for Women's Health, University College London, Gower Street, London WC1E 6BT, UK.
E-O FourkalaWomen's Cancer, Institute for Women's Health, University College London, Gower Street, London WC1E 6BT, UK.
S ApostolidouWomen's Cancer, Institute for Women's Health, University College London, Gower Street, London WC1E 6BT, UK.
R GunuWomen's Cancer, Institute for Women's Health, University College London, Gower Street, London WC1E 6BT, UK.
A RyanWomen's Cancer, Institute for Women's Health, University College London, Gower Street, London WC1E 6BT, UK.
I Jacobs1] Women's Cancer, Institute for Women's Health, University College London, Gower Street, London WC1E 6BT, UK [2] Faculty of Medical and Human Sciences, 1.018 Core Technology Facility, University of Manchester, Grafton Street Manchester M13 9NT, UK.
U MenonWomen's Cancer, Institute for Women's Health, University College London, Gower Street, London WC1E 6BT, UK.
W AldertonAbcodia Ltd, The Network Building, 97 Tottenham Court Road, London W1T 4TP, UK.
A Gentry-MaharajWomen's Cancer, Institute for Women's Health, University College London, Gower Street, London WC1E 6BT, UK.
J F TimmsWomen's Cancer, Institute for Women's Health, University College London, Gower Street, London WC1E 6BT, UK.
University College London · GBAbcodia (United Kingdom) · GBUniversity of Manchester · GB

Funding

Cancer Research UKDepartment of HealthMedical Research Council G0801228Medical Research Council G9901012Medical Research Council MR/J006718/1
6 · The paper itself

Abstract

backgroundBlood-borne biomarkers for early detection of colorectal cancer (CRC) could markedly increase screening uptake. The aim of this study was to evaluate serum carcinoembryonic antigen (CEA), CYFRA21-1 and CA125 for the early detection of CRC in an asymptomatic cohort.

methodsThis nested case-control study within UKCTOCS used 381 serial serum samples from 40 women subsequently diagnosed with CRC, 20 women subsequently diagnosed with benign disease and 40 matched non-cancer controls with three to four samples per subject taken annually up to 4 years before diagnosis. CEA, CYFRA21-1 and CA125 were measured using validated assays and performance of markers evaluated for different pre-diagnosis time groups.

resultsCEA levels increased towards diagnosis in a third of all cases (half of late-stage cases), whereas longitudinal profiles were static in both benign and non-cancer controls. At a threshold of >5 ng ml(-1) the sensitivities for detecting CRC up to 1 and 4 years before clinical presentation were 25% and 13%, respectively, at 95% specificity. At a threshold of >2.5 ng ml(-1), sensitivities were 57.5% and 38.4%, respectively, with specificities of 81% and 83.5%. CYFRA21-1 and CA125 had no utility as screening markers and did not enhance CEA performance when used in combination. CEA gave average lead times of 17-24 months for test-positive cases.

conclusionsCEA is elevated in a significant proportion of individuals with preclinical CRC, but would not be useful alone as a screening tool. This work sets a baseline from which to develop panels of biomarkers which combine CEA for improved early detection of CRC.

Indexed as

Early Detection of CancerAdultAgedAntigens, NeoplasmCA-125 AntigenCarcinoembryonic AntigenCase-Control StudiesColorectal NeoplasmsFemaleHumansKeratin-19Longitudinal StudiesMiddle Agedantigen CYFRA21.1Antigens, NeoplasmCA-125 AntigenCarcinoembryonic AntigenKeratin-19

Identifiers

PMID26035703
PMCPMC4506388
OpenAlexW1553554982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.