ReviewNature reviews. Gastroenterology & hepatology2015
Peroral endoscopic myotomy: an evolving treatment for achalasia.
Review in Nature reviews. Gastroenterology & hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Factors associated with peroral endoscopic myotomy for achalasia outcomes: systematic review and meta-analysis.Surgical endoscopy · 2024Pooled it
- Efficacy and Safety of Peroral Endoscopic Myotomy for Sigmoid-Type Achalasia: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Gastric myotomy length affects severity but not rate of post-procedure reflux: 3-year follow-up of a prospective randomized controlled trial of double-scope per-oral endoscopic myotomy (POEM) for esophageal achalasia.Surgical endoscopy · 2020Trial
- Saudi Gastroenterology Association (SGA) clinical care pathway and standards of care for peroral endoscopic myotomy (POEM) in achalasia.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2026Article
- Surgical and endoscopic interventions in the management of idiopathic achalasia.The Cochrane database of systematic reviews · 2025Article
- Identification of potential drug targets for achalasia from genetic insights: a Mendelian randomization study.Journal of cardiothoracic surgery · 2025Article
- Peroral endoscopic myotomy for complex achalasia and the POEM difficulty score: An update.DEN open · 2025Article
- Long-term efficacy of peroral endoscopic myotomy for achalasia under different criteria.Surgical endoscopy · 2024Article
- Peroral endoscopic myotomy in the presence of small esophageal varices.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2024Article
- Successful Endoscopic Submucosal Dissection Using Open Peroral Endoscopic Myotomy for Duodenal Neuroendocrine Tumor.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2024Article
- Patient Position in Operative Endoscopy.Journal of clinical medicine · 2023Review
- Peroral Endoscopic Myotomy for Achalasia in Older Adults: A Retrospective Analysis of 39 Cases with a Minimum Follow-Up of 5 Years.Dysphagia · 2023Article
- Per-oral endoscopic myotomy is safe and effective for pediatric patients with achalasia: A long-term follow-up study.World journal of gastroenterology · 2023Article
- Pathogenesis, clinical manifestations, diagnosis, and treatment progress of achalasia of cardia.World journal of clinical cases · 2023Review
- Usefulness of Endoscopy for the Detection and Diagnosis of Primary Esophageal Motility Disorders and Diseases Relating to Abnormal Esophageal Motility.Diagnostics (Basel, Switzerland) · 2023Review
- Peroral Endoscopic Myotomy for Pediatric Achalasia: A Retrospective Analysis of 21 Cases With a Minimum Follow-Up of 5 Years.Frontiers in pediatrics · 2022Article
- Advances in gastrointestinal surgical endoscopy.Annals of medicine and surgery (2012) · 2021Review
- Treatment challenges of sigmoid-shaped esophagus and severe achalasia.Annals of medicine and surgery (2012) · 2021Review
- Peroral Endoscopic Myotomy for Esophageal Motility Disorders.Clinical endoscopy · 2020Article
- Peroral endoscopic shorter versus longer myotomy for the treatment of achalasia: a comparative retrospective study.Esophagus : official journal of the Japan Esophageal Society · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peroral endoscopic myotomy (POEM) was first performed in Japan in 2008 for uncomplicated achalasia. With excellent results, it was adopted by highly skilled endoscopists around the world and the indications for POEM were expanded to include advanced sigmoid achalasia, failed surgical myotomy, patients with previous endoscopic treatments and even other spastic oesophageal motility disorders. With increased uptake and performance of POEM, variations in technique and improved management of adverse events have been developed. Now, 6 years since the first case and with >3,000 procedures performed worldwide, long-term data has shown the efficacy of POEM to be long-lasting. A growing body of literature also exists pertaining to the learning curve, application of novel technologies, extended indications and physiologic changes with POEM. Ultimately, this once experimental procedure is evolving towards becoming the preferred treatment for achalasia and other spastic oesophageal motility disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.