ReviewJournal of clinical neurophysiology : official publication of the American Electroencephalographic Society2015
Conundrums of high-frequency oscillations (80-800 Hz) in the epileptic brain.
Review in Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Hippocampal microcircuits constrain the generation of epileptiform activity.bioRxiv : the preprint server for biology · 2026Article
- Opposing interictal dynamics in Alzheimer's disease and epilepsy.Progress in neurobiology · 2026Article
- AI-based localization of the epileptogenic zone using intracranial EEG.Epilepsia open · 2025Review
- High-frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Hippocampal and cortical high-frequency oscillations orchestrate human semantic networks during word list memory.iScience · 2025Article
- A machine learning toolbox for the analysis of sharp-wave ripples reveals common waveform features across species.Communications biology · 2024Article
- Robust chronic convulsive seizures, high frequency oscillations, and human seizure onset patterns in an intrahippocampal kainic acid model in mice.Neurobiology of disease · 2022Article
- Microscale dynamics of electrophysiological markers of epilepsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
- Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap.Nature reviews. Neurology · 2021Review
- Characterizing Hippocampal Oscillatory Signatures Underlying Seizures in Temporal Lobe Epilepsy.Frontiers in behavioral neuroscience · 2021Review
- Laminar distribution of electrically evoked hippocampal short latency ripple activity highlights the importance of the subiculum in vivo in human epilepsy, an intraoperative study.Epilepsy research · 2021Article
- High frequency oscillations in epileptic and non-epileptic human hippocampus during a cognitive task.Scientific reports · 2020Observational
- Long-range phase synchronization of high-frequency oscillations in human cortex.Nature communications · 2020Article
- Association of fast ripples on intracranial EEG and outcomes after epilepsy surgery.Neurology · 2020Article
- Trends in the use of automated algorithms for the detection of high-frequency oscillations associated with human epilepsy.Epilepsia · 2020Review
- Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis.Epilepsy research · 2019Article
- MEEGIPS-A Modular EEG Investigation and Processing System for Visual and Automated Detection of High Frequency Oscillations.Frontiers in neuroinformatics · 2019Article
- Bispectrum Features and Multilayer Perceptron Classifier to Enhance Seizure Prediction.Scientific reports · 2018Article
- Electrophysiological Evidence for the Development of a Self-Sustained Large-Scale Epileptic Network in the Kainate Mouse Model of Temporal Lobe Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Utilization of independent component analysis for accurate pathological ripple detection in intracranial EEG recordings recorded extra- and intra-operatively.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018Article
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Funding
Abstract
Pathological high-frequency oscillations (HFOs) (80-800 Hz) are considered biomarkers of epileptogenic tissue, but the underlying complex neuronal events are not well understood. Here, we identify and discuss several outstanding issues or conundrums in regards to the recording, analysis, and interpretation of HFOs in the epileptic brain to critically highlight what is known and what is not about these enigmatic events. High-frequency oscillations reflect a range of neuronal processes contributing to overlapping frequencies from the lower 80 Hz to the very fast spectral frequency bands. Given their complex neuronal nature, HFOs are extremely sensitive to recording conditions and analytical approaches. We provide a list of recommendations that could help to obtain comparable HFO signals in clinical and basic epilepsy research. Adopting basic standards will facilitate data sharing and interpretation that collectively will aid in understanding the role of HFOs in health and disease for translational purpose.
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