ReviewJournal of clinical neurophysiology : official publication of the American Electroencephalographic Society2015
Future of seizure prediction and intervention: closing the loop.
Review in Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Medical Technology: A Systematic Review on Medical Devices Utilized for Epilepsy Prediction and Management.Current neuropharmacology · 2022Pooled it
- Surface EEG-Transcranial Direct Current Stimulation (tDCS) Closed-Loop System.International journal of neural systems · 2017Trial
- Differential roles of NaeLife · 2025Article
- Assessing Thresholds for Nerve Activation and Action Potential Block Using a Multielectrode Array to Minimize External Stimulation.Bioengineering (Basel, Switzerland) · 2025Article
- The bidirectional relationship between the cerebellum and seizure networks: a double-edged sword.Current opinion in behavioral sciences · 2023Article
- Optogenetic stimulation of the superior colliculus suppresses genetic absence seizures.Brain : a journal of neurology · 2023Article
- Computational modeling allows unsupervised classification of epileptic brain states across species.Scientific reports · 2023Article
- Multielectrode Cortical Stimulation Selectively Induces Unidirectional Wave Propagation of Excitatory Neuronal Activity in Biophysical Neural Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- LINCs Are Vulnerable to Epileptic Insult and Fail to Provide Seizure Control via On-Demand Activation.eNeuro · 2023Article
- Using Constrained Square-Root Cubature Kalman Filter for Quantifying the Severity of Epileptic Activities in Mice.Biomedicines · 2022Article
- A Patient Perspective on Seizure Detection and Forecasting.Frontiers in neurology · 2022Article
- The cerebellum and epilepsy.Epilepsy & behavior : E&B · 2021Review
- Stimulating Solutions for Intractable Epilepsy.Epilepsy currents · 2021Article
- Active probing to highlight approaching transitions to ictal states in coupled neural mass models.PLoS computational biology · 2021Article
- Toward Closed-Loop Electrical Stimulation of Neuronal Systems: A Review.Bioelectricity · 2020Review
- Diverse Applications of Artificial Intelligence in Neuroradiology.Neuroimaging clinics of North America · 2020Review
- Big data in status epilepticus.Epilepsy & behavior : E&B · 2019Review
- Selective recruitment of cortical neurons by electrical stimulation.PLoS computational biology · 2019Article
- Outgrowing seizures in Childhood Absence Epilepsy: time delays and bistability.Journal of computational neuroscience · 2019Article
- Ultra Broad Band Neural Activity Portends Seizure Onset in a Rat Model of Epilepsy.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The ultimate goal of epilepsy therapies is to provide seizure control for all patients while eliminating side effects. Improved specificity of intervention through on-demand approaches may overcome many of the limitations of current intervention strategies. This article reviews the progress in seizure prediction and detection, potential new therapies to provide improved specificity, and devices to achieve these ends. Specifically, we discuss (1) potential signal modalities and algorithms for seizure detection and prediction, (2) closed-loop intervention approaches, and (3) hardware for implementing these algorithms and interventions. Seizure prediction and therapies maximize efficacy, whereas minimizing side effects through improved specificity may represent the future of epilepsy treatments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.