ArticleToxins2015
Nivalenol has a greater impact than deoxynivalenol on pig jejunum mucosa in vitro on explants and in vivo on intestinal loops.
Article in Toxins, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Differential gene expression to heat stress drives thermotolerance, pathogenicity, and reproduction in Fusarium head blight pathogens: from transcriptomic profiling to functional validation.BMC plant biology · 2026Article
- Article
- Fusarium Head Blight in Barley from Subtropical Southern Brazil: AssociatedPlants (Basel, Switzerland) · 2025Article
- Sub-acute oral exposure to lowest observed adverse effect level of nivalenol exacerbates atopic dermatitis in mice via direct activation of mitogen-activated protein kinase signal in antigen-presenting cells.Archives of toxicology · 2024Article
- China-origin G1 group isolate FPV072 exhibits higher infectivity and pathogenicity than G2 group isolate FPV027.Frontiers in veterinary science · 2024Article
- Review
- Effect of Temperature, Water Activity and Incubation Time on Trichothecene Production byPathogens (Basel, Switzerland) · 2023Article
- Infection timing affects Fusarium poae colonization of bread wheat spikes and mycotoxin accumulation in the grain.Journal of the science of food and agriculture · 2022Article
- Article
- Review
- Article
- Article
- The Presence of Mycotoxins in Human Amniotic Fluid.Toxins · 2021Article
- Impaired Performance of Broiler Chickens Fed Diets Naturally Contaminated with Moderate Levels of Deoxynivalenol.Toxins · 2021Article
- Article
- Maternal Supplementation of Food Ingredient (Prebiotic) or Food Contaminant (Mycotoxin) Influences Mucosal Immune System in Piglets.Nutrients · 2020Article
- Multiple Fungal Metabolites Including Mycotoxins in Naturally Infected andMicroorganisms · 2020Article
- Article
- The impact of chlorophyllin on deoxynivalenol transport across jejunum mucosa explants obtained from adult pigs.Mycotoxin research · 2019Article
- Appropriateness to set a group health based guidance value for nivalenol and its modified forms.EFSA journal. European Food Safety Authority · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mycotoxins deoxynivalenol (DON) and nivalenol (NIV), worldwide cereal contaminants, raise concerns for animal and human gut health, following contaminated food or feed ingestion. The impact of DON and NIV on intestinal mucosa was investigated after acute exposure, in vitro and in vivo. The histological changes induced by DON and NIV were analyzed after four-hour exposure on pig jejunum explants and loops, two alternative models. On explants, dose-dependent increases in the histological changes were induced by DON and NIV, with a two-fold increase in lesion severity at 10 µM NIV. On loops, NIV had a greater impact on the mucosa than DON. The overall proliferative cells showed 30% and 13% decrease after NIV and DON exposure, respectively, and NIV increased the proliferative index of crypt enterocytes. NIV also increased apoptosis at the top of villi and reduced by almost half the proliferative/apoptotic cell ratio. Lamina propria cells (mainly immune cells) were more sensitive than enterocytes (epithelial cells) to apoptosis induced by NIV. Our results demonstrate a greater impact of NIV than DON on the intestinal mucosa, both in vitro and in vivo, and highlight the need of a specific hazard characterization for NIV risk assessment.
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