ReviewToxins2015
Treatment of gastrointestinal sphincters spasms with botulinum toxin A.
Review in Toxins, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Impact of Botulinum Neurotoxin Pyloric Injection During Laparoscopic Sleeve Gastrectomy on Postoperative Gastric Leak: a Clinical Randomized Study.Obesity surgery · 2016Trial
- Therapy with botulinum neurotoxin for Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Is chemodenervation with incobotulinumtoxinA an alternative to invasive chronic anal fissure treatments?BMC gastroenterology · 2024Article
- Article
- Esophageal Achalasia: Pros and Cons of the Treatment Options.World journal of surgery · 2022Review
- Review
- Review
- The Role of Botox in Colorectal Disorders.Current treatment options in gastroenterology · 2018Review
- The Role of Botulinum Toxin Injections for Esophageal Motility Disorders.Current treatment options in gastroenterology · 2018Review
- High-dose versus low-dose botulinum toxin in anal fissure disease.Techniques in coloproctology · 2017Article
- Chronic constipation in Rome IV era: The Indian perspective.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2017Review
- Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology.Pharmacological reviews · 2017Review
- Impact of botulinum toxin A injection on esophageal anastomosis in a rabbit model.Pediatric surgery international · 2016Article
- Can gastric botulinum toxin A injection be used as minimally invasive procedure in the short-term treatment of obesity?Journal of minimal access surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Botulinum toxin A inhibits neuromuscular transmission. It has become a drug with many indications. The range of clinical applications has grown to encompass several neurological and non-neurological conditions. One of the most recent achievements in the field is the observation that botulinum toxin A provides benefit in diseases of the gastrointestinal tract. Although toxin blocks cholinergic nerve endings in the autonomic nervous system, it has also been shown that it does not block non-adrenergic non-cholinergic responses mediated by nitric oxide. This has promoted further interest in using botulinum toxin A as a treatment for overactive smooth muscles and sphincters. The introduction of this therapy has made the treatment of several clinical conditions easier, in the outpatient setting, at a lower cost and without permanent complications. This review presents current data on the use of botulinum toxin A in the treatment of pathological conditions of the gastrointestinal tract.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.