ReviewNutrients2015
Vitamin D every day to keep the infection away?
Review in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Infection Status of Rural Schoolchildren and its Relationship with Vitamin D Concentrations.Indian journal of pediatrics · 2019Trial
- Molecular Insight into the Role of Vitamin D in Immune-Mediated Inflammatory Diseases.International journal of molecular sciences · 2025Review
- Micronutrient inadequacy in Europe: the overlooked role of food supplements in health resilience.Frontiers in nutrition · 2025Review
- Therapeutic and protective approaches to combatFrontiers in pharmacology · 2025Review
- Vitamin D and Its Receptors in Cervical Cancer.Journal of Cancer · 2024Review
- Post-Transplant Vitamin D Deficiency in Lung Transplant Recipients: Impact on Outcomes and Prognosis.Transplant international : official journal of the European Society for Organ Transplantation · 2024Observational
- The role of micronutrients in the management of COIVD-19 and optimizing vaccine efficacy.Human nutrition & metabolism · 2022Review
- Vitamin D supplementation for autoimmune hepatitis: A need for further investigation.World journal of hepatology · 2022Article
- Vitamin D3 is well Correlated with Anti-Advanced biomedical research · 2022Article
- Multiple Micronutrient Supplementation: As a Supportive Therapy in the Treatment of COVID-19.BioMed research international · 2022Review
- Effects of vitamin D supplementation on the functional outcome in patients with osteoporotic vertebral compression fracture and vitamin D deficiency.Journal of orthopaedic surgery and research · 2021Article
- Vitamin D status and complications, readmissions, and mortality after hip fracture.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Vitamin D3 as Potential Treatment Adjuncts for COVID-19.Nutrients · 2020Review
- Dietary micronutrients in the wake of COVID-19: an appraisal of evidence with a focus on high-risk groups and preventative healthcare.BMJ nutrition, prevention & health · 2020Review
- Vitamin D as a Principal Factor in Mediating Rheumatoid Arthritis-Derived Immune Response.BioMed research international · 2019Review
- Observational
- Vitamin D Compounds Are Bactericidal against Streptococcus mutans and Target the Bacitracin-Associated Efflux System.Antimicrobial agents and chemotherapy · 2018Article
- Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance.Frontiers in immunology · 2018Review
- 1,25(OH)American journal of translational research · 2018Article
- Vitamin D in Human Immunodeficiency Virus Infection: Influence on Immunity and Disease.Frontiers in immunology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Within the last decade, vitamin D has emerged as a central regulator of host defense against infections. In this regard, vitamin D triggers effective antimicrobial pathways against bacterial, fungal and viral pathogens in cells of the human innate immune system. However, vitamin D also mediates potent tolerogenic effects: it is generally believed that vitamin D attenuates inflammation and acquired immunity, and thus potentially limits collateral tissue damage. Nevertheless, several studies indicate that vitamin D promotes aspects of acquired host defense. Clinically, vitamin D deficiency has been associated with an increased risk for various infectious diseases in epidemiological studies; yet, robust data from controlled trials investigating the use of vitamin D as a preventive or therapeutic agent are missing. In this review, we summarize the current knowledge regarding the effect of vitamin D on innate and acquired host defense, and speculate on the difficulties to translate the available molecular medicine data into practical therapeutic or preventive recommendations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.