Evidence map›Paper›PMID 26035220›Full record

ArticleA & A case reports2015

Emergence delirium with transient associative agnosia and expressive aphasia reversed by flumazenil in a pediatric patient.

Julie K Drobish, Max B Kelz, Patricia M DiPuppo, Scott D Cook-Sather

Abstract readCase Reports
In one paragraph

Article in A & A case reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Recycle: Do It for the Kids.Journal of cardiothoracic and vascular anesthesia · 2020
    Article
  6. Article
  7. Review
  8. Observational
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Julie K DrobishFrom the Departments of *Anesthesiology and Critical Care Medicine and ‡Nursing, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; and †Department of Anesthesiology and Critical Care, Perelman School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Max B Kelz
Patricia M DiPuppo
Scott D Cook-Sather

Funding

NEURONAL BASIS UNDERLYING VOLATILE ANESTHETIC INDUCED HYPNOSISR01GM088156 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KELZ, MAX · 2010 to 2021
$3.8M
OptoanesthesiaR01GM107117 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KELZ, MAX · 2014 to 2017
$1.3M
NIGMS NIH HHS R01 GM088156NIGMS NIH HHS R01 GM107117
6 · The paper itself

Abstract

Multiple factors may contribute to the development of emergence delirium in a child. We present the case of a healthy 12-year-old girl who received preoperative midazolam with the desired anxiolytic effect, underwent a brief general anesthetic, and then exhibited postoperative delirium, consisting of a transient associative agnosia and expressive aphasia. Administration of flumazenil led to immediate and lasting resolution of her symptoms. We hypothesize that γ-aminobutyric acid type A receptor-mediated effects, most likely related to an atypical offset of midazolam, are an important subset of emergence delirium that is amenable to pharmacologic therapy with flumazenil.

Indexed as

Adjuvants, AnesthesiaAgnosiaAnesthesia, GeneralAphasia, BrocaChildDeliriumFemaleFlumazenilGABA-A Receptor AntagonistsHumansMidazolamPostoperative ComplicationsAdjuvants, AnesthesiaFlumazenilGABA-A Receptor AntagonistsMidazolam

Identifiers

PMID26035220
PMCPMC4455039

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.