ArticleTranslational psychiatry2015
Altered functional connectivity of the cingulate subregions in schizophrenia.
Article in Translational psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 6 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Identification of a diagnosis-selective neurobiological substrate for bipolar disorder, major depressive disorder, and schizophrenia: a meta-analysis of 57,717 subjects.Psychological medicine · 2026Pooled it
- Altered brain functional networks in schizophrenia with persistent negative symptoms: an activation likelihood estimation meta-analysis.Frontiers in human neuroscience · 2023Pooled it
- Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review.Frontiers in human neuroscience · 2022Pooled it
- Meta-analysis of structural and functional brain abnormalities in schizophrenia with persistent negative symptoms using activation likelihood estimation.Frontiers in psychiatry · 2022Pooled it
- Dysconnectivity of Multiple Brain Networks in Schizophrenia: A Meta-Analysis of Resting-State Functional Connectivity.Frontiers in psychiatry · 2019Pooled it
- Dysfunction of Large-Scale Brain Networks in Schizophrenia: A Meta-analysis of Resting-State Functional Connectivity.Schizophrenia bulletin · 2018Pooled it
- N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study.The international journal of neuropsychopharmacology · 2019Trial
- Nicotinic modulation of salience network connectivity and centrality in schizophrenia.Journal of psychiatric research · 2017Trial
- Disrupted neural response timing and duration during hand movement preparation in schizophrenia spectrum disorder: An fMRI study.Scientific reports · 2026Article
- Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression.Journal of neurochemistry · 2026Review
- Age-dependent cortical overconnectivity in Shank3 mice is reversed by anesthesia.Translational psychiatry · 2025Article
- Distinct effects of global signal regression on brain activity during propofol and sevoflurane anesthesia.Frontiers in neuroscience · 2025Article
- Distinct resting-state functional connectivity of the anterior cingulate cortex subregions in first-episode schizophrenia.Brain imaging and behavior · 2024Article
- Article
- Explainable fuzzy clustering framework reveals divergent default mode network connectivity dynamics in schizophrenia.Frontiers in psychiatry · 2024Article
- Article
- Brain subnetworks most sensitive to alterations of functional connectivity in Schizophrenia: a data-driven approach.Frontiers in neuroinformatics · 2023Article
- Cortical thickness across the cingulate gyrus in schizophrenia and its association to illness duration and memory performance.European archives of psychiatry and clinical neuroscience · 2022Article
- Treatment Effect of Long-Term Antipsychotics on Default-Mode Network Dysfunction in Drug-Naïve Patients With First-Episode Schizophrenia: A Longitudinal Study.Frontiers in pharmacology · 2022Article
- Aberrant Dynamic Functional Connectivity of Default Mode Network in Schizophrenia and Links to Symptom Severity.Frontiers in neural circuits · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia patients have shown altered resting-state functional connectivity (rsFC) of the cingulate cortex; however, it is unknown whether rsFCs of the cingulate subregions are differentially affected in this disorder. We aimed to clarify the issue by comparing rsFCs of each cingulate subregion between healthy controls and schizophrenia patients. A total of 102 healthy controls and 94 schizophrenia patients underwent resting-state functional magnetic resonance imaging with a sensitivity-encoded spiral-in imaging sequence to reduce susceptibility-induced signal loss and distortion. The cingulate cortex was divided into nine subregions, including the subgenual anterior cingulate cortex (ACC), areas 24 and 32 of the pregenual ACC, areas 24 and 32 of the anterior mid-cingulate cortex (aMCC), posterior MCC (pMCC), dorsal (dPCC) and ventral (vPCC) posterior cingulate cortex (PCC) and retrosplenial cortex (RSC). The rsFCs of each cingulate subregion were compared between the two groups and the atrophy effect was considered. Results with and without global signal regression were reported. Most cingulate subregions exhibited decreased rsFCs in schizophrenia after global signal regression (GSR). Without GSR, only increased rsFC was found in schizophrenia, which primarily restricted to the aMCC, PCC and RSC. Some of these increased rsFCs were also significant after GSR. These findings suggest that GSR can greatly affect between-group differences in rsFCs and the consistently increased rsFCs may challenge the functional disconnection hypothesis of schizophrenia.
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