ArticleScientific reports2015
Age-dependent variation in cytokines, chemokines, and biologic analytes rinsed from the surface of healthy human skin.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Barrier Function and Biophysical Effects of 0.104% and 0.247% Retinol Creams in Mature Facial Skin: A Prospective Study.International journal of molecular sciences · 2026Trial
- Skin aging: mechanisms, evaluation, and rejuvenation.The EMBO journal · 2026Review
- A global perspective on the treatment and maintenance of mature skin using gentle cleansers and moisturizers.International journal of dermatology · 2024Review
- Topical application of jojoba (Frontiers in pharmacology · 2024Article
- Skin Cancer Microenvironment: What We Can Learn from Skin Aging?International journal of molecular sciences · 2023Review
- Biomarkers of aging.Science China. Life sciences · 2023Review
- Immunosenescence and Skin: A State of Art of Its Etiopathogenetic Role and Crucial Watershed for Systemic Implications.International journal of molecular sciences · 2023Review
- Review
- Proinflammatory profile in the skin of Parkinson's disease patients with and without pain.PloS one · 2022Article
- Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 Contributes to Epidermal Permeability Barrier Dysfunction in Aged Skin.International journal of molecular sciences · 2021Article
- Topical Zinc Oxide Assessed in Two Human Wound-healing Models.Acta dermato-venereologica · 2021Article
- Cellular Senescence and Inflammaging in the Skin Microenvironment.International journal of molecular sciences · 2021Review
- Sampling interstitial fluid from human skin using a microneedle patch.Science translational medicine · 2020Article
- Niche rather than origin dysregulates mucosal Langerhans cells development in aged mice.Mucosal immunology · 2020Article
- A Simple Method for the Production of Human Skin Equivalent in 3D, Multi-Cell Culture.International journal of molecular sciences · 2020Article
- Review
- The Interaction of Age and Anatomical Region Influenced Skin Biophysical Characteristics of Chinese Women.Clinical, cosmetic and investigational dermatology · 2020Article
- N-Terminal Acetylation and C-Terminal Amidation ofMarine drugs · 2019Article
- Article
- ELIPatch, a thumbnail-size patch with immunospot array for multiplexed protein detection from human skin surface.Biomicrofluidics · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
In the skin, aging is associated with overall epidermal thinning, decreased barrier function, and gradual deterioration of the epidermal immune response. However, the presence and role of cytokines, chemokines, and biologic analytes (CCBAs) in immunosenescence are not known. Here we identified age-related changes in skin properties and CCBAs from stratum corneum of healthy human subjects, providing a means to utilize CCBAs as benchmarks for aging skin health. Transepidermal water loss and a(*) (skin redness) decreased in an age-dependent manner, and were significantly lower (p < 0.05) in Groups 2 (56.6 ± 4.6 years) and 3 (72.9 ± 3.0 years) vs. Group 1 (24.3 ± 2.8 years). In skin wash fluid, 48 CCBAs were detected; seven were significantly lower (p < 0.05) in Groups 2 and 3: EGF, FGF-2, IFNα2, IL-1RA, HSA, keratin-6, and involucrin; cortisol was significantly higher (p < 0.05) in Groups 2 and 3. Our results correspond with the pro-inflammatory shift that occurs with immunosenescence and also provides basis for understanding the inflammatory changes in normal aging skin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.