ArticlePloS one2015
Response of the cholesterol metabolism to a negative energy balance in dairy cows depends on the lactational stage.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 66 citations in OpenAlex.
- FeedingVeterinary and animal science · 2026Article
- Genomic partitioning and functional dissection of inbreeding depression for stature in Brown Swiss cattle.Genetics, selection, evolution : GSE · 2026Article
- Foetal Mummification in Pregnant Dairy Cows Induces Variant Changes on the Hormonal Profile, Biochemical Parameters and Mineral Profile of the Dam.Veterinary medicine and science · 2025Article
- Molecular Characteristics and Role of BuffaloGenes · 2025Article
- Structural equation models to infer relationships between energy-related blood metabolites and milk daily energy output in Holstein cows.Journal of animal science · 2024Article
- Article
- Metabolic Changes Associated with Different Levels of Energy Deficits in Mediterranean Buffaloes during the Early Lactation Stage: Type and Role of the Main Lipid Fractions Involved.Animals : an open access journal from MDPI · 2023Article
- Effect of short time precise dietary energy-protein in reproductive parameters of local crossbred dairy goats.Journal of advanced veterinary and animal research · 2023Article
- Agarose gel electrophoresis determination of bovine lipoproteins compared with a wet chemistry method.JDS communications · 2022Article
- Limiting factors for milk production in dairy cows: perspectives from physiology and nutrition.Journal of animal science · 2022Review
- The Correlation between Extracellular Heat Shock Protein 70 and Lipid Metabolism in a Ruminant Model.Metabolites · 2021Article
- Article
- Comparison of cholesterol levels among lipoprotein fractions separated by anion-exchange high-performance liquid chromatography in periparturient Holstein-Friesian dairy cows.The Journal of veterinary medical science · 2021Article
- Physical exercise prepartum to support metabolic adaptation in the transition period of dairy cattle: A proof of concept.Journal of animal physiology and animal nutrition · 2020Article
- Identification of Plasma Fatty Acids in Four Lipid Classes to Understand Energy Metabolism at Different Levels of Ketonemia in Dairy Cows Using Thin Layer Chromatography and Gas Chromatographic Techniques (TLC-GC).Animals : an open access journal from MDPI · 2020Article
- Article
- Effects of Developmental Programming Caused by Maternal Nutrient Intake on Postnatal Performance of Beef Heifers and Their Calves.Animals : an open access journal from MDPI · 2019Article
- Genome wide association study identifies novel potential candidate genes for bovine milk cholesterol content.Scientific reports · 2018Article
- Metabolic Profile and Inflammatory Responses in Dairy Cows with Left Displaced Abomasum Kept under Small-Scaled Farm Conditions.Animals : an open access journal from MDPI · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The response of cholesterol metabolism to a negative energy balance (NEB) induced by feed restriction for 3 weeks starting at 100 days in milk (DIM) compared to the physiologically occurring NEB in week 1 postpartum (p.p.) was investigated in 50 dairy cows (25 control (CON) and 25 feed-restricted (RES)). Blood samples, liver biopsies and milk samples were taken in week 1 p.p., and in weeks 0 and 3 of feed restriction. Plasma concentrations of total cholesterol (C), phospholipids (PL), triglycerides (TAG), very low density lipoprotein-cholesterol (VLDL-C) and low density lipoprotein-cholesterol (LDL-C) increased in RES cows from week 0 to 3 during feed restriction and were higher in week 3 compared to CON cows. In contrast, during the physiologically occurring NEB in week 1 p.p., C, PL, TAG and lipoprotein concentrations were at a minimum. Plasma phospholipid transfer protein (PLTP) and lecithin:cholesterol acyltransferase (LCAT) activities did not differ between week 0 and 3 for both groups, whereas during NEB in week 1 p.p. PLTP activity was increased and LCAT activity was decreased. Milk C concentration was not affected by feed restriction in both groups, whereas milk C mass was decreased in week 3 for RES cows. In comparison, C concentration and mass in milk were elevated in week 1 p.p. Hepatic mRNA abundance of sterol regulatory element-binding factor-2 (SREBF-2), 3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 (HMGCS1), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), and ATP-binding cassette transporter (ABCA1) were similar in CON and RES cows during feed restriction, but were upregulated during NEB in week 1 p.p. compared to the non-lactating stage without a NEB. In conclusion, cholesterol metabolism in dairy cows is affected by nutrient and energy deficiency depending on the stage of lactation.
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