ArticlePloS one2015
Accuracy and feasibility of point-of-care white blood cell count and C-reactive protein measurements at the pediatric emergency department.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03540706 (Impact of the Use of C-reactive Protein in a Micro-method on the Prescription of Antibiotics in General Practitioners Consulting in the Office), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of the Use of C-reactive Protein in a Micro-method on the Prescription of Antibiotics in General Practitioners Consulting in the Office
Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Evaluation of point-of-care complete blood count and C-reactive protein testing for routine use in a pediatric emergency department.European journal of pediatrics · 2026Article
- Availability of diagnostic tools and stewardship protocols for managing infectious diseases in Italian paediatric emergency departments: a nationwide survey.Italian journal of pediatrics · 2026Article
- Comparison between point-of-care testing from capillary samples and conventional laboratory testing from venous samples for white blood cells and C-reactive protein in a pediatric outpatient setting.Journal of general and family medicine · 2025Article
- The value of the INFECTIONS scoring system in identifying bacterial infections among patients presenting at the emergency department of a middle-income country: A pilot study.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2024Article
- Comparison of commercially available, rapid, point-of-care C-reactive protein assays among children with febrile illness in southwestern Uganda.PLOS global public health · 2024Article
- Flexible and Innovative Connectivity Solution to Support National Decentralized Infectious Diseases Point-of-Care Testing Programs in Primary Health Services: Descriptive Evaluation Study.Journal of medical Internet research · 2023Article
- Preparing of Point-of-Care Reagents for Risk Assessment in the Elderly at Home by a Home-Visit Nurse and Verification of Their Analytical Accuracy.Diagnostics (Basel, Switzerland) · 2023Article
- Analytical verification of the Dymind D7-CRP automated analyser.Biochemia medica · 2023Article
- Could combined rapid diagnostic testing for malaria and c-reactive protein be helpful for the diagnosis and management of febrile illnesses in children under-5 years of age in rural Burkina Faso?BMC infectious diseases · 2022Article
- Point-of-care C-reactive protein test results in acute infections in children in primary care: an observational study.BMC pediatrics · 2022Observational
- Implementation factor mapping of a pilot study of point-of-care C-reactive protein testing for respiratory tract infections in community pharmacy.Exploratory research in clinical and social pharmacy · 2022Article
- Article
- Distinct Biomarker Profiles Distinguish Malawian Children with Malarial and Non-malarial Sepsis.The American journal of tropical medicine and hygiene · 2019Article
- Comparison of the use of comprehensive point-of-care test panel to conventional laboratory process in emergency department.BMC emergency medicine · 2018Observational
- Accuracy of Complete Blood Cell Counts to Identify Febrile Infants 60 Days or Younger With Invasive Bacterial Infections.JAMA pediatrics · 2017Observational
- Embedding new technologies in practice - a normalization process theory study of point of care testing.BMC health services research · 2016Article
- Article
- Predicting mortality in pediatric sepsis: A laudable but elusive goal.Jornal de pediatriaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral point-of-care (POC) tests are available for evaluation of febrile patients, but the data about their performance in acute care setting is sparse. We investigated the analytical accuracy and feasibility of POC tests for white blood cell (WBC) count and C-reactive protein (CRP) at the pediatric emergency department (ED).
methodsIn the first part of the study, HemoCue WBC and Afinion AS100 CRP POC analyzers were compared with laboratory's routine WBC (Sysmex XE-2100) and CRP (Modular P) analyzers in the hospital central laboratory in 77 and 48 clinical blood samples, respectively. The POC tests were then adopted in use at the pediatric ED. In the second part of the study, we compared WBC and CRP levels measured by POC and routine methods during 171 ED patient visits by 168 febrile children and adolescents. Attending physicians performed POC tests in capillary fingerprick samples.
resultsIn parallel measurements in the laboratory both WBC and CRP POC analyzers showed good agreement with the reference methods. In febrile children at the emergency department (median age 2.4 years), physician performed POC determinations in capillary blood gave comparable results with those in venous blood analyzed in the laboratory. The mean difference between POC and reference test result was 1.1 E9/L (95% limits of agreement from -6.5 to 8.8 E9/L) for WBC and -1.2 mg/L (95% limits of agreement from -29.6 to 27.2 mg/L) for CRP.
conclusionsPOC tests are feasible and relatively accurate methods to assess CRP level and WBC count among febrile children at the ED.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.