Evidence map›Paper›PMID 26034894›Full record

ReviewAnnual review of biochemistry2015

A molecular description of cellulose biosynthesis.

Joshua T McNamara, Jacob L W Morgan, Jochen Zimmer

Open access · greenAbstract readReview
In one paragraph

Review in Annual review of biochemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed
33.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 362 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. A molecular description of plant cellulose biosynthesis inhibition.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Fungal Chitin Synthases: Structure, Function, and Regulation.Journal of fungi (Basel, Switzerland) · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Cellulase Production by Ultraviolet-Derived MutantInternational journal of molecular sciences · 2025
    Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article

67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joshua T McNamaraCenter for Membrane Biology, Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908; email: Jtm4r@virginia.edu , Jlm2qp@virginia.edu , jochen_zimmer@virginia.edu.
Jacob L W Morgan
Jochen Zimmer
University of Virginia · US

Funding

Mechanism of Cellulose Synthesis and Transport Across Biological MembranesR01GM101001 · NIGMS · UNIVERSITY OF VIRGINIA · PI ZIMMER, JOCHEN · 2012 to 2021
$3.7M
NIGMS NIH HHS 1R01GM101001NIGMS NIH HHS R01 GM101001
6 · The paper itself

Abstract

Cellulose is the most abundant biopolymer on Earth, and certain organisms from bacteria to plants and animals synthesize cellulose as an extracellular polymer for various biological functions. Humans have used cellulose for millennia as a material and an energy source, and the advent of a lignocellulosic fuel industry will elevate it to the primary carbon source for the burgeoning renewable energy sector. Despite the biological and societal importance of cellulose, the molecular mechanism by which it is synthesized is now only beginning to emerge. On the basis of recent advances in structural and molecular biology on bacterial cellulose synthases, we review emerging concepts of how the enzymes polymerize glucose molecules, how the nascent polymer is transported across the plasma membrane, and how bacterial cellulose biosynthesis is regulated during biofilm formation. Additionally, we review evolutionary commonalities and differences between cellulose synthases that modulate the nature of the cellulose product formed.

Indexed as

Catalytic DomainCelluloseCell WallElectron TransportMixed Function OxygenasesPlantsCelluloseMixed Function Oxygenasesbiofilmcellulose synthasecyclic di-GMPexopolysaccharide biosynthesismembrane transportprocessive glycosyltransferase

Identifiers

PMID26034894
PMCPMC4710354
OpenAlexW2171511525

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.