Evidence map›Paper›PMID 26034611›Full record

ArticleNeuro-oncology practice2014

The incidence of cerebrovascular accidents and second brain tumors in patients with pituitary adenoma: a population-based study.

Paul D Brown, Miran Blanchard, Krishan Jethwa, Kelly D Flemming, Cerise A Brown, Robert W Kline, Debra J Jacobson, Jennifer St Sauver, Bruce E Pollock, Yolanda I Garces and 5 more

Open access · bronzeAbstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in Neuro-oncology practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed, 1 pooled it

1.1field-weighted citation impact, top 22% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

Ischemic stroke after radiation therapy for pituitary adenomas: a systematic review.Journal of neuro-oncology · 2017
Pooled it
High-precision stereotactic irradiation for focal drug-resistant epilepsy versus standard treatment: a randomized waitlist-controlled trial (the PRECISION trial).Trials · 2024
Trial
Management after initial surgery of nonfunctioning pituitary adenoma: surveillance, radiotherapy or surgery?Radiation oncology (London, England) · 2022
Article
Long-term safety of gamma knife radiosurgery (SRS) for acromegaly.Pituitary · 2021
Article
Incidence of myocardial infarction and stroke in acromegaly patients: results from the German Acromegaly Registry.Pituitary · 2017
Article
STEREOTACTIC RADIATION THERAPY IN PITUITARY ADENOMAS, IS IT BETTER THAN CONVENTIONAL RADIATION THERAPY?Acta endocrinologica (Bucharest, Romania : 2005)
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Paul D BrownDepartment of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston, Texas (P.D.B.); Department of Radiation Oncology , Mayo Clinic , Rochester, New York (P.D.B., M.B., C.A.B., R.W.K., B.E.P., Y.I.G., S.L.S., R.L.F., N.N.I.L.); School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota (K.J.); Department of Neurology , Mayo Clinic , Rochester, New York (K.D.F.); Department of Health Sciences Research , Mayo Clinic , Rochester, New York (D.J.J., J.S.); Department of Neurosurgery , Mayo Clinic , Rochester, New York (B.E.P., M.J.L.); Department of Endocrinology, Metabolism and Nutrition , Mayo Clinic , Rochester, New York (D.E.).

Miran BlanchardDepartment of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston, Texas (P.D.B.); Department of Radiation Oncology , Mayo Clinic , Rochester, New York (P.D.B., M.B., C.A.B., R.W.K., B.E.P., Y.I.G., S.L.S., R.L.F., N.N.I.L.); School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota (K.J.); Department of Neurology , Mayo Clinic , Rochester, New York (K.D.F.); Department of Health Sciences Research , Mayo Clinic , Rochester, New York (D.J.J., J.S.); Department of Neurosurgery , Mayo Clinic , Rochester, New York (B.E.P., M.J.L.); Department of Endocrinology, Metabolism and Nutrition , Mayo Clinic , Rochester, New York (D.E.).

Krishan JethwaDepartment of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston, Texas (P.D.B.); Department of Radiation Oncology , Mayo Clinic , Rochester, New York (P.D.B., M.B., C.A.B., R.W.K., B.E.P., Y.I.G., S.L.S., R.L.F., N.N.I.L.); School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota (K.J.); Department of Neurology , Mayo Clinic , Rochester, New York (K.D.F.); Department of Health Sciences Research , Mayo Clinic , Rochester, New York (D.J.J., J.S.); Department of Neurosurgery , Mayo Clinic , Rochester, New York (B.E.P., M.J.L.); Department of Endocrinology, Metabolism and Nutrition , Mayo Clinic , Rochester, New York (D.E.).

Kelly D FlemmingDepartment of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston, Texas (P.D.B.); Department of Radiation Oncology , Mayo Clinic , Rochester, New York (P.D.B., M.B., C.A.B., R.W.K., B.E.P., Y.I.G., S.L.S., R.L.F., N.N.I.L.); School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota (K.J.); Department of Neurology , Mayo Clinic , Rochester, New York (K.D.F.); Department of Health Sciences Research , Mayo Clinic , Rochester, New York (D.J.J., J.S.); Department of Neurosurgery , Mayo Clinic , Rochester, New York (B.E.P., M.J.L.); Department of Endocrinology, Metabolism and Nutrition , Mayo Clinic , Rochester, New York (D.E.).

Cerise A BrownDepartment of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston, Texas (P.D.B.); Department of Radiation Oncology , Mayo Clinic , Rochester, New York (P.D.B., M.B., C.A.B., R.W.K., B.E.P., Y.I.G., S.L.S., R.L.F., N.N.I.L.); School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota (K.J.); Department of Neurology , Mayo Clinic , Rochester, New York (K.D.F.); Department of Health Sciences Research , Mayo Clinic , Rochester, New York (D.J.J., J.S.); Department of Neurosurgery , Mayo Clinic , Rochester, New York (B.E.P., M.J.L.); Department of Endocrinology, Metabolism and Nutrition , Mayo Clinic , Rochester, New York (D.E.).

Robert W KlineDepartment of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston, Texas (P.D.B.); Department of Radiation Oncology , Mayo Clinic , Rochester, New York (P.D.B., M.B., C.A.B., R.W.K., B.E.P., Y.I.G., S.L.S., R.L.F., N.N.I.L.); School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota (K.J.); Department of Neurology , Mayo Clinic , Rochester, New York (K.D.F.); Department of Health Sciences Research , Mayo Clinic , Rochester, New York (D.J.J., J.S.); Department of Neurosurgery , Mayo Clinic , Rochester, New York (B.E.P., M.J.L.); Department of Endocrinology, Metabolism and Nutrition , Mayo Clinic , Rochester, New York (D.E.).

Debra J JacobsonDepartment of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston, Texas (P.D.B.); Department of Radiation Oncology , Mayo Clinic , Rochester, New York (P.D.B., M.B., C.A.B., R.W.K., B.E.P., Y.I.G., S.L.S., R.L.F., N.N.I.L.); School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota (K.J.); Department of Neurology , Mayo Clinic , Rochester, New York (K.D.F.); Department of Health Sciences Research , Mayo Clinic , Rochester, New York (D.J.J., J.S.); Department of Neurosurgery , Mayo Clinic , Rochester, New York (B.E.P., M.J.L.); Department of Endocrinology, Metabolism and Nutrition , Mayo Clinic , Rochester, New York (D.E.).

Jennifer St SauverDepartment of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston, Texas (P.D.B.); Department of Radiation Oncology , Mayo Clinic , Rochester, New York (P.D.B., M.B., C.A.B., R.W.K., B.E.P., Y.I.G., S.L.S., R.L.F., N.N.I.L.); School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota (K.J.); Department of Neurology , Mayo Clinic , Rochester, New York (K.D.F.); Department of Health Sciences Research , Mayo Clinic , Rochester, New York (D.J.J., J.S.); Department of Neurosurgery , Mayo Clinic , Rochester, New York (B.E.P., M.J.L.); Department of Endocrinology, Metabolism and Nutrition , Mayo Clinic , Rochester, New York (D.E.).

Bruce E PollockDepartment of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston, Texas (P.D.B.); Department of Radiation Oncology , Mayo Clinic , Rochester, New York (P.D.B., M.B., C.A.B., R.W.K., B.E.P., Y.I.G., S.L.S., R.L.F., N.N.I.L.); School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota (K.J.); Department of Neurology , Mayo Clinic , Rochester, New York (K.D.F.); Department of Health Sciences Research , Mayo Clinic , Rochester, New York (D.J.J., J.S.); Department of Neurosurgery , Mayo Clinic , Rochester, New York (B.E.P., M.J.L.); Department of Endocrinology, Metabolism and Nutrition , Mayo Clinic , Rochester, New York (D.E.).

Yolanda I GarcesDepartment of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston, Texas (P.D.B.); Department of Radiation Oncology , Mayo Clinic , Rochester, New York (P.D.B., M.B., C.A.B., R.W.K., B.E.P., Y.I.G., S.L.S., R.L.F., N.N.I.L.); School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota (K.J.); Department of Neurology , Mayo Clinic , Rochester, New York (K.D.F.); Department of Health Sciences Research , Mayo Clinic , Rochester, New York (D.J.J., J.S.); Department of Neurosurgery , Mayo Clinic , Rochester, New York (B.E.P., M.J.L.); Department of Endocrinology, Metabolism and Nutrition , Mayo Clinic , Rochester, New York (D.E.).

Scott L StaffordDepartment of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston, Texas (P.D.B.); Department of Radiation Oncology , Mayo Clinic , Rochester, New York (P.D.B., M.B., C.A.B., R.W.K., B.E.P., Y.I.G., S.L.S., R.L.F., N.N.I.L.); School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota (K.J.); Department of Neurology , Mayo Clinic , Rochester, New York (K.D.F.); Department of Health Sciences Research , Mayo Clinic , Rochester, New York (D.J.J., J.S.); Department of Neurosurgery , Mayo Clinic , Rochester, New York (B.E.P., M.J.L.); Department of Endocrinology, Metabolism and Nutrition , Mayo Clinic , Rochester, New York (D.E.).

Michael J LinkDepartment of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston, Texas (P.D.B.); Department of Radiation Oncology , Mayo Clinic , Rochester, New York (P.D.B., M.B., C.A.B., R.W.K., B.E.P., Y.I.G., S.L.S., R.L.F., N.N.I.L.); School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota (K.J.); Department of Neurology , Mayo Clinic , Rochester, New York (K.D.F.); Department of Health Sciences Research , Mayo Clinic , Rochester, New York (D.J.J., J.S.); Department of Neurosurgery , Mayo Clinic , Rochester, New York (B.E.P., M.J.L.); Department of Endocrinology, Metabolism and Nutrition , Mayo Clinic , Rochester, New York (D.E.).

Dana EricksonDepartment of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston, Texas (P.D.B.); Department of Radiation Oncology , Mayo Clinic , Rochester, New York (P.D.B., M.B., C.A.B., R.W.K., B.E.P., Y.I.G., S.L.S., R.L.F., N.N.I.L.); School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota (K.J.); Department of Neurology , Mayo Clinic , Rochester, New York (K.D.F.); Department of Health Sciences Research , Mayo Clinic , Rochester, New York (D.J.J., J.S.); Department of Neurosurgery , Mayo Clinic , Rochester, New York (B.E.P., M.J.L.); Department of Endocrinology, Metabolism and Nutrition , Mayo Clinic , Rochester, New York (D.E.).

Robert L FooteDepartment of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston, Texas (P.D.B.); Department of Radiation Oncology , Mayo Clinic , Rochester, New York (P.D.B., M.B., C.A.B., R.W.K., B.E.P., Y.I.G., S.L.S., R.L.F., N.N.I.L.); School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota (K.J.); Department of Neurology , Mayo Clinic , Rochester, New York (K.D.F.); Department of Health Sciences Research , Mayo Clinic , Rochester, New York (D.J.J., J.S.); Department of Neurosurgery , Mayo Clinic , Rochester, New York (B.E.P., M.J.L.); Department of Endocrinology, Metabolism and Nutrition , Mayo Clinic , Rochester, New York (D.E.).

Nadia N I LaackDepartment of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston, Texas (P.D.B.); Department of Radiation Oncology , Mayo Clinic , Rochester, New York (P.D.B., M.B., C.A.B., R.W.K., B.E.P., Y.I.G., S.L.S., R.L.F., N.N.I.L.); School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota (K.J.); Department of Neurology , Mayo Clinic , Rochester, New York (K.D.F.); Department of Health Sciences Research , Mayo Clinic , Rochester, New York (D.J.J., J.S.); Department of Neurosurgery , Mayo Clinic , Rochester, New York (B.E.P., M.J.L.); Department of Endocrinology, Metabolism and Nutrition , Mayo Clinic , Rochester, New York (D.E.).

Mayo Clinic · USThe University of Texas MD Anderson Cancer Center · USUniversity of North Dakota · USWinnMed · USMayo Clinic in Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo assess the risk of cerebrovascular accidents (CVAs) and second brain tumors (SBTs) in patients with pituitary adenoma after surgery or radiotherapy.

methodsA cohort of 143 people from Olmsted County, who were diagnosed with pituitary adenoma between 1933 and 2000, was studied. Only patients from Olmsted County were included because of the unique nature of medical care in Olmsted County, which allows the ascertainment of virtually all cases of pituitary adenoma for this community's residents and comparisons to the general population in the county. Surgical resection was performed in 76 patients, 29 patients underwent radiotherapy (with 21 undergoing both surgery and radiotherapy), 5 patients were reirradiated, and 59 patients were managed conservatively and observed.

resultsMedian follow-up was 15.5 years. There was no difference in CVA-free survival between treatment groups. On univariate analysis age > 60 years (hazard ratio [HR], 11.93; 95% CI, 6.26-23.03;

conclusionCVA is a significant risk for patients with pituitary tumors, but treatment does not seem to impact the risk. Even with long-term follow-up, SBTs are a rare event regardless of treatment modality.

Indexed as

pituitary adenomaradiotherapysecondary malignancystrokesurgery

Identifiers

PMID26034611

DOI10.1093/nop/npt001

PMCPMC4369699

OpenAlexW2052625810

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.