ArticleAntimicrobial resistance and infection control2015
The impact of antimicrobial allergy labels on antimicrobial usage in cancer patients.
Article in Antimicrobial resistance and infection control, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 66 citations in OpenAlex.
- Article
- Article
- Impact of beta-lactam allergy labels on bone marrow transplant patients.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Antibiotic use and financial impact of a comprehensive beta-lactam allergy management program.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Implementation and outcomes of beta-lactam allergy management protocol at a comprehensive cancer center.Infection · 2024Article
- Patient-related factors impact the implementation of inpatient antibiotic allergy delabeling.The journal of allergy and clinical immunology. Global · 2024Article
- A call to address penicillin allergy labels in patients with hematopoietic stem cell transplants: How to avoid rash decisions.Transplant infectious disease : an official journal of the Transplantation Society · 2024Review
- Penicillin allergy evaluation in hospitalized patients with hematologic malignancy.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Safety and value of pretransplant antibiotic allergy delabeling in a quaternary transplant center.Transplant infectious disease : an official journal of the Transplantation Society · 2022Article
- Immediate and Delayed Hypersensitivity Reactions to Beta-Lactam Antibiotics.Clinical reviews in allergy & immunology · 2022Review
- The feasibility and generalizability of assessing the appropriateness of antimicrobial prescribing in hospitals: a review of the Australian National Antimicrobial Prescribing Survey.JAC-antimicrobial resistance · 2022Review
- It's a rash: Antibiotic allergies in the modern era of antibiotic stewardship.International journal of pediatric otorhinolaryngology · 2021Article
- Focus group study exploring the issues and the solutions to incorrect penicillin allergy-labelled patients: an antibiotic stewardship patient safety initiative.European journal of hospital pharmacy : science and practice · 2021Article
- Development and Validation of a Penicillin Allergy Clinical Decision Rule.JAMA internal medicine · 2020Article
- High-cost, high-need patients: the impact of reported penicillin allergy.The American journal of managed care · 2020Article
- High prevalence of antibiotic allergies in cladribine-treated patients with hairy cell leukemia - lessons for immunopathogenesis and prescribing.Leukemia & lymphoma · 2019Article
- Article
- Antibiotic allergy labels in hospitalized and critically ill adults: A review of current impacts of inaccurate labelling.British journal of clinical pharmacology · 2019Review
- Antibiotic allergy.Lancet (London, England) · 2019Review
- The Safety and Efficacy of an Oral Penicillin Challenge Program in Cancer Patients: A Multicenter Pilot Study.Open forum infectious diseases · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntibiotic allergy labels are associated with sub-optimal prescribing patterns and poorer clinical outcomes in non-cancer populations, but the effect of labelling on antimicrobial usage in patients with cancer is unknown.
findingsA retrospective review of hospitalized patients admitted to the Peter MacCallum Cancer Centre (2010-2012) identified 23 % of cancer patients (n = 198) with an antimicrobial allergy label (AA). Comparison of those with an antimicrobial allergy label to those without demonstrated increased antibiotic use per admission (3 vs. 2, p = 0.01), increased fluoroquinolone use (11 % vs. 6 %, p < 0.05), increased antibiotic course duration (15 vs. 13 days, p = 0.09), higher readmission rates (53 % vs. 28 %, p < 0.001) and poorer concordance with prescribing guidelines (47 % vs. 91 %, p < 0.001). Patients in the AA group on multivariate analysis had a higher number of antibiotics employed, longer duration of antibiotic therapy and higher rate of readmission.
conclusionsAntimicrobial usage, including the use of restricted antibiotics, is higher in patients with cancer. Antibiotic de-labelling strategies in cancer patients must be evaluated to aid antimicrobial stewardship initiatives.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.