Evidence map›Paper›PMID 26034427›Full record

ArticleHand (New York, N.Y.)2015

Prospective cohort study of symptom resolution outside of the ulnar nerve distribution following cubital tunnel release.

Peter C Chimenti, Allison W McIntyre, Sean M Childs, Warren C Hammert, John C Elfar

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hand (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04026568 phase2 / phase3terminatednot on this mapstarted 2021, after this paper: background citation

A Single Dose Pharmaco-Diagnostic for Peripheral Nerve Continuity After Trauma

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2021 to 2022Enrolled1ConditionsNerve InjuryArms4-Aminopyridine, Placebo oral tablet
NCT06003166 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Pharmaco-Diagnostic Crossover Trial for Peripheral Nerve Continuity After Trauma

TypeinterventionalSponsorUniversity of ArizonaRan2025 to 2028Enrolled68ConditionsPeripheral Nerve Injury, Crush InjuryArms4-Aminopyridine, Placebo
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Peter C ChimentiDepartment of Orthopaedic Surgery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642 USA.
Allison W McIntyreDepartment of Orthopaedic Surgery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642 USA.
Sean M ChildsDepartment of Orthopaedic Surgery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642 USA.
Warren C HammertDepartment of Orthopaedic Surgery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642 USA.
John C ElfarDepartment of Orthopaedic Surgery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642 USA.
University of Rochester Medical Center · US

Funding

Erythropoietin for NeuroregenerationK08AR060164 · NIAMS · UNIVERSITY OF ROCHESTER · PI ELFAR, JOHN · 2013 to 2017
$578k
NIAMS NIH HHS K08 AR060164
6 · The paper itself

Abstract

backgroundResolution of symptoms including pain, numbness, and tingling outside of the median nerve distribution has been shown to occur following carpal tunnel release. We hypothesized that a similar effect would be found after release of the ulnar nerve at the elbow.

methodsTwenty patients with isolated cubital tunnel syndrome were prospectively enrolled. The upper extremity was divided into six zones, and the location of pain, numbness, tingling, or strange sensations was recorded pre-operatively. Two-point discrimination, Semmes-Weinstein monofilament testing, and validated questionnaires were collected. The same data were collected at 6-week follow-up. Paired t tests or non-parametric Wilcoxon Signed-Rank tests were used where appropriate to examine for significant (p ≤ 0.05) changes between pre- and post-operative scores.

resultsProbability of resolution was greater outside of the ulnar nerve distribution than within at early follow-up. There was a decrease in pain, numbness, and tingling symptoms both within and outside the ulnar distribution after cubital tunnel release. There was a decrease in pain as measured by several validated questionnaires.

conclusionThis study documents resolution of symptoms in an extra-ulnar distribution after cubital tunnel release. Improvement in pain and function after cubital tunnel release may be associated with an improvement in symptoms both within and outside the ulnar nerve distribution. Future studies could be directed at correlating pre-operative disease severity with probability of extra-territorial symptom resolution using a larger sample population.

Indexed as

Cubital tunnel syndromeExtra-ulnarUlnar nerveUlnar neuropathy

Identifiers

PMID26034427
PMCPMC4447657
OpenAlexW2007088993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.