ArticleWorld journal of gastroenterology2015
Laboratory test variables useful for distinguishing upper from lower gastrointestinal bleeding.
Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Association between a 24-h increase in blood urea nitrogen and clinical outcomes in acute non-variceal upper gastrointestinal bleeding: a dual-center retrospective cohort study.Therapeutic advances in gastroenterology · 2026Article
- Predicting Adverse Outcomes in Upper Gastrointestinal Bleeding: A Focus on Blood Urea Nitrogen-Based Ratios and Age-Adjusted Shock Index.Emergency medicine international · 2026Article
- Reconsidering the urea-to-creatinine ratio as a signal of muscle catabolism in patients with cirrhosis.Critical care (London, England) · 2025Article
- Lactate to albumin ratio as a prognosis predictor in gastrointestinal bleeding in the emergency department.Internal and emergency medicine · 2025Article
- The role of BUN/creatinine ratio in determining the severity of gastrointestinal bleeding and bleeding localization.Northern clinics of Istanbul · 2025Article
- Plasma urea:creatinine ratio as a biomarker of gastrointestinal bleeding in dogs with anaemia.Veterinary medicine and science · 2023Article
- Bleeding Complications in Uremic Patients After Ultrasound-Guided Central Venous Catheter Placement.Open access emergency medicine : OAEM · 2023Article
- Observational
- Diagnostic evaluation of urea nitrogen/creatinine ratio in dogs with gastrointestinal bleeding.Journal of veterinary internal medicine · 2021Article
- Blood Urea Nitrogen to Creatinine ratio in Differentiation of Upper and Lower Gastrointestinal Bleedings; a Diagnostic Accuracy Study.Archives of academic emergency medicine · 2019Article
- Change ratio of hemoglobin has predictive value for upper gastrointestinal bleeding.Biomedical reports · 2016Article
- Low hemoglobin levels are associated with upper gastrointestinal bleeding.Biomedical reports · 2016Article
- Elevated C-reactive protein level predicts lower gastrointestinal tract bleeding.Biomedical reports · 2016Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo distinguish upper from lower gastrointestinal (GI) bleeding.
methodsPatient records between April 2011 and March 2014 were analyzed retrospectively (3296 upper endoscopy, and 1520 colonoscopy). Seventy-six patients had upper GI bleeding (Upper group) and 65 had lower GI bleeding (Lower group). Variables were compared between the groups using one-way analysis of variance. Logistic regression was performed to identify variables significantly associated with the diagnosis of upper vs lower GI bleeding. Receiver-operator characteristic (ROC) analysis was performed to determine the threshold value that could distinguish upper from lower GI bleeding.
resultsHemoglobin (P = 0.023), total protein (P = 0.0002), and lactate dehydrogenase (P = 0.009) were significantly lower in the Upper group than in the Lower group. Blood urea nitrogen (BUN) was higher in the Upper group than in the Lower group (P = 0.0065). Logistic regression analysis revealed that BUN was most strongly associated with the diagnosis of upper vs lower GI bleeding. ROC analysis revealed a threshold BUN value of 21.0 mg/dL, with a specificity of 93.0%.
conclusionThe threshold BUN value for distinguishing upper from lower GI bleeding was 21.0 mg/dL.
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