ArticleInfection and immunity2015
Preserved dendritic cell HLA-DR expression and reduced regulatory T cell activation in asymptomatic Plasmodium falciparum and P. vivax infection.
Article in Infection and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria.Malaria journal · 2022Article
- Reduced circulating dendritic cells in acute Plasmodium knowlesi and Plasmodium falciparum malaria despite elevated plasma Flt3 ligand levels.Malaria journal · 2021Article
- Dendritic cell responses to Plasmodium falciparum in a malaria-endemic setting.Malaria journal · 2021Article
- The Impact of Malaria Parasites on Dendritic Cell-T Cell Interaction.Frontiers in immunology · 2020Review
- Plasmodium falciparum Activates CD16+ Dendritic Cells to Produce Tumor Necrosis Factor and Interleukin-10 in Subpatent Malaria.The Journal of infectious diseases · 2019Article
- Dendritic Cell Responses and Function in Malaria.Frontiers in immunology · 2019Review
- Plasmodium vivax Infection Impairs Regulatory T-Cell Suppressive Function During Acute Malaria.The Journal of infectious diseases · 2018Article
- Characterization of T cell activation and regulation in children with asymptomatic Plasmodium falciparum infection.Malaria journal · 2018Article
- Longitudinal study of changes in γδ T cells and CD4Scientific reports · 2017Article
- Plasmacytoid dendritic cells appear inactive during sub-microscopic Plasmodium falciparum blood-stage infection, yet retain their ability to respond to TLR stimulation.Scientific reports · 2017Article
- Early Immune Regulatory Changes in a Primary Controlled Human Plasmodium vivax Infection: CD1cInfection and immunity · 2017Article
- Assay of Peripheral Regulatory Vδ1 T Cells in Ankylosing Spondylitis and its Significance.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Characterization of blood dendritic and regulatory T cells in asymptomatic adults with sub-microscopic Plasmodium falciparum or Plasmodium vivax infection.Malaria journal · 2016Article
- Profoundly Reduced CD1c+ Myeloid Dendritic Cell HLA-DR and CD86 Expression and Increased Tumor Necrosis Factor Production in Experimental Human Blood-Stage Malaria Infection.Infection and immunity · 2016Article
- Malaria Parasites: The Great Escape.Frontiers in immunology · 2016Review
- Dendritic Cells and Their Multiple Roles during Malaria Infection.Journal of immunology research · 2016Review
- Immunoregulation in human malaria: the challenge of understanding asymptomatic infection.Memorias do Instituto Oswaldo Cruz · 2015Review
- Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria.PLoS pathogens · 2015Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
Abstract
Clinical illness with Plasmodium falciparum or Plasmodium vivax compromises the function of dendritic cells (DC) and expands regulatory T (Treg) cells. Individuals with asymptomatic parasitemia have clinical immunity, restricting parasite expansion and preventing clinical disease. The role of DC and Treg cells during asymptomatic Plasmodium infection is unclear. During a cross-sectional household survey in Papua, Indonesia, we examined the number and activation of blood plasmacytoid DC (pDC), CD141(+), and CD1c(+) myeloid DC (mDC) subsets and Treg cells using flow cytometry in 168 afebrile children (of whom 15 had P. falciparum and 36 had P. vivax infections) and 162 afebrile adults (of whom 20 had P. falciparum and 20 had P. vivax infections), alongside samples from 16 patients hospitalized with uncomplicated malaria. Unlike DC from malaria patients, DC from children and adults with asymptomatic, microscopy-positive P. vivax or P. falciparum infection increased or retained HLA-DR expression. Treg cells in asymptomatic adults and children exhibited reduced activation, suggesting increased immune responsiveness. The pDC and mDC subsets varied according to clinical immunity (asymptomatic or symptomatic Plasmodium infection) and, in asymptomatic infection, according to host age and parasite species. In conclusion, active control of asymptomatic infection was associated with and likely contingent upon functional DC and reduced Treg cell activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.