Evidence map›Paper›PMID 26034121›Full record

ArticleEndocrine connections2015

Steroidogenic enzyme profile in an androgen-secreting adrenocortical oncocytoma associated with hirsustism.

Milène Tetsi Nomigni, Sophie Ouzounian, Alice Benoit, Jacqueline Vadrot, Frédérique Tissier, Sylvie Renouf, Hervé Lefebvre, Sophie Christin-Maitre, Estelle Louiset

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine connections, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Adrenocortical oncocytoma associated with androgen excess: A rare cause of hirsutism.Indian journal of urology : IJU : journal of the Urological Society of India
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Milène Tetsi NomigniINSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France University of Rouen Mont-Saint-Aignan, France Department of Endocrinology Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France Departments of Endocrinology Diabetes and Metabolic Diseases Pathology Hôpital Sud Francilien, Corbeil-Essonnes, France Department of Pathology Assistance Publique des Hôpitaux de Paris, Hôpital Pitié Salpétrière, Pierre-et-Marie Curie University, Paris, France Department of Endocrinology Diabetes and Metabolic Diseases, Rouen University Hospital, 76000 Rouen, France INSERM U933, Paris, France INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France University of Rouen Mont-Saint-Aignan, France Department of Endocrinology Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France Departments of Endocrinology Diabetes and Metabolic Diseases Pathology Hôpital Sud Francilien, Corbeil-Essonnes, France Department of Pathology Assistance Publique des Hôpitaux de Paris, Hôpital Pitié Salpétrière, Pierre-et-Marie Curie University, Paris, France Department of Endocrinology Diabetes and Metabolic Diseases, Rouen University Hospital, 76000 Rouen, France INSERM U933, Paris, France.
Sophie OuzounianINSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France University of Rouen Mont-Saint-Aignan, France Department of Endocrinology Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France Departments of Endocrinology Diabetes and Metabolic Diseases Pathology Hôpital Sud Francilien, Corbeil-Essonnes, France Department of Pathology Assistance Publique des Hôpitaux de Paris, Hôpital Pitié Salpétrière, Pierre-et-Marie Curie University, Paris, France Department of Endocrinology Diabetes and Metabolic Diseases, Rouen University Hospital, 76000 Rouen, France INSERM U933, Paris, France.
Alice BenoitINSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France University of Rouen Mont-Saint-Aignan, France Department of Endocrinology Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France Departments of Endocrinology Diabetes and Metabolic Diseases Pathology Hôpital Sud Francilien, Corbeil-Essonnes, France Department of Pathology Assistance Publique des Hôpitaux de Paris, Hôpital Pitié Salpétrière, Pierre-et-Marie Curie University, Paris, France Department of Endocrinology Diabetes and Metabolic Diseases, Rouen University Hospital, 76000 Rouen, France INSERM U933, Paris, France.
Jacqueline VadrotINSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France University of Rouen Mont-Saint-Aignan, France Department of Endocrinology Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France Departments of Endocrinology Diabetes and Metabolic Diseases Pathology Hôpital Sud Francilien, Corbeil-Essonnes, France Department of Pathology Assistance Publique des Hôpitaux de Paris, Hôpital Pitié Salpétrière, Pierre-et-Marie Curie University, Paris, France Department of Endocrinology Diabetes and Metabolic Diseases, Rouen University Hospital, 76000 Rouen, France INSERM U933, Paris, France.
Frédérique TissierINSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France University of Rouen Mont-Saint-Aignan, France Department of Endocrinology Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France Departments of Endocrinology Diabetes and Metabolic Diseases Pathology Hôpital Sud Francilien, Corbeil-Essonnes, France Department of Pathology Assistance Publique des Hôpitaux de Paris, Hôpital Pitié Salpétrière, Pierre-et-Marie Curie University, Paris, France Department of Endocrinology Diabetes and Metabolic Diseases, Rouen University Hospital, 76000 Rouen, France INSERM U933, Paris, France.
Sylvie RenoufINSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France University of Rouen Mont-Saint-Aignan, France Department of Endocrinology Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France Departments of Endocrinology Diabetes and Metabolic Diseases Pathology Hôpital Sud Francilien, Corbeil-Essonnes, France Department of Pathology Assistance Publique des Hôpitaux de Paris, Hôpital Pitié Salpétrière, Pierre-et-Marie Curie University, Paris, France Department of Endocrinology Diabetes and Metabolic Diseases, Rouen University Hospital, 76000 Rouen, France INSERM U933, Paris, France INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France University of Rouen Mont-Saint-Aignan, France Department of Endocrinology Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France Departments of Endocrinology Diabetes and Metabolic Diseases Pathology Hôpital Sud Francilien, Corbeil-Essonnes, France Department of Pathology Assistance Publique des Hôpitaux de Paris, Hôpital Pitié Salpétrière, Pierre-et-Marie Curie University, Paris, France Department of Endocrinology Diabetes and Metabolic Diseases, Rouen University Hospital, 76000 Rouen, France INSERM U933, Paris, France.
Hervé LefebvreINSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France University of Rouen Mont-Saint-Aignan, France Department of Endocrinology Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France Departments of Endocrinology Diabetes and Metabolic Diseases Pathology Hôpital Sud Francilien, Corbeil-Essonnes, France Department of Pathology Assistance Publique des Hôpitaux de Paris, Hôpital Pitié Salpétrière, Pierre-et-Marie Curie University, Paris, France Department of Endocrinology Diabetes and Metabolic Diseases, Rouen University Hospital, 76000 Rouen, France INSERM U933, Paris, France INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France University of Rouen Mont-Saint-Aignan, France Department of Endocrinology Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France Departments of Endocrinology Diabetes and Metabolic Diseases Pathology Hôpital Sud Francilien, Corbeil-Essonnes, France Department of Pathology Assistance Publique des Hôpitaux de Paris, Hôpital Pitié Salpétrière, Pierre-et-Marie Curie University, Paris, France Department of Endocrinology Diabetes and Metabolic Diseases, Rouen University Hospital, 76000 Rouen, France INSERM U933, Paris, France INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France University of Rouen Mont-Saint-Aignan, France Department of Endocrinology Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France Departments of Endocrinology Diabetes and Metabolic Diseases Pathology Hôpital Sud Francilien, Corbeil-Essonnes, France Department of Pathology Assistance Publique des Hôpitaux de Paris, Hôpital Pitié Salpétrière, Pierre-e
Sophie Christin-MaitreINSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France University of Rouen Mont-Saint-Aignan, France Department of Endocrinology Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France Departments of Endocrinology Diabetes and Metabolic Diseases Pathology Hôpital Sud Francilien, Corbeil-Essonnes, France Department of Pathology Assistance Publique des Hôpitaux de Paris, Hôpital Pitié Salpétrière, Pierre-et-Marie Curie University, Paris, France Department of Endocrinology Diabetes and Metabolic Diseases, Rouen University Hospital, 76000 Rouen, France INSERM U933, Paris, France INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France University of Rouen Mont-Saint-Aignan, France Department of Endocrinology Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France Departments of Endocrinology Diabetes and Metabolic Diseases Pathology Hôpital Sud Francilien, Corbeil-Essonnes, France Department of Pathology Assistance Publique des Hôpitaux de Paris, Hôpital Pitié Salpétrière, Pierre-et-Marie Curie University, Paris, France Department of Endocrinology Diabetes and Metabolic Diseases, Rouen University Hospital, 76000 Rouen, France INSERM U933, Paris, France.
Estelle LouisetINSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France University of Rouen Mont-Saint-Aignan, France Department of Endocrinology Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France Departments of Endocrinology Diabetes and Metabolic Diseases Pathology Hôpital Sud Francilien, Corbeil-Essonnes, France Department of Pathology Assistance Publique des Hôpitaux de Paris, Hôpital Pitié Salpétrière, Pierre-et-Marie Curie University, Paris, France Department of Endocrinology Diabetes and Metabolic Diseases, Rouen University Hospital, 76000 Rouen, France INSERM U933, Paris, France INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont-Saint-Aignan, France University of Rouen Mont-Saint-Aignan, France Department of Endocrinology Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France Departments of Endocrinology Diabetes and Metabolic Diseases Pathology Hôpital Sud Francilien, Corbeil-Essonnes, France Department of Pathology Assistance Publique des Hôpitaux de Paris, Hôpital Pitié Salpétrière, Pierre-et-Marie Curie University, Paris, France Department of Endocrinology Diabetes and Metabolic Diseases, Rouen University Hospital, 76000 Rouen, France INSERM U933, Paris, France.
Inserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hirsutism induced by hyperandrogenism can be associated with polycystic ovary syndrome, 21-hydroxylase (OH) deficiency or androgen-secreting tumors, including ovarian and adrenal tumors. Adrenal androgen-secreting tumors are frequently malignant. Adrenal oncocytomas represent rare causes of hyperandrogenism. The aim of the study was to investigate steroidogenic enzyme expression and steroid secretion in an androgen-secreting adrenal oncocytoma in a young woman presenting with hirsutism. Hyperandrogenism was diagnosed on the basis of elevated plasma Δ4-androstenedione and testosterone levels. Pelvic ultrasound was normal, CT scanning revealed a right adrenal mass. Androgens were assessed in adrenal and ovarian vein samples and proved a right adrenal origin. Adrenalectomy normalized androgen levels and the adrenal tumor was diagnosed as an oncocytoma. Real time-PCR, immunohistochemistry and cell culture studies were performed on tumor explants to investigate the steroid secretion profile. Among enzymes required for cortisol synthesis, 17α-OH and 3β-hydroxysteroid dehydrogenase 2 (3β-HSD2) were highly expressed whereas 21-OH and 11β-OH were weakly produced at the mRNA and/or protein levels. Enzymes involved in testosterone production, 17β-HSD5 and 17β-HSD3, were also detected. ACTH receptor was present in the tissue. Cortisol, Δ4-androstenedione and testosterone secretions by cultured cells were increased by ACTH. These results provide the first demonstration, to our knowledge, of abnormal expression profile of steroidogenic enzymes in an adrenocortical oncocytoma. Our results also indicate that Δ4-androstenedione hypersecretion resulted from high 17α-OH and 3β-HSD2 expression in combination with low expression of 21-OH and 11β-OH. Testosterone production was ascribed to occurrence of 17β-HSD5 and 17β-HSD3. Finally, our results indicate that androgen secretion was stimulated by ACTH.

Indexed as

androgen-producing oncocytomacortisolhirsutismtestosteroneΔ4-androstenedione

Identifiers

PMID26034121
PMCPMC4453718
OpenAlexW2123463609

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.