ReviewOrthopaedic surgery2015
Progress on clinical characteristics and identification of location of thoracic ossification of the ligamentum flavum.
Review in Orthopaedic surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- The prevalence and clinical characteristics of thoracic spinal stenosis: a systematic review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020Pooled it
- Biomechanical comparison of laminoplasty and in-site regrafting versus laminectomy with pedicle screw fixation for localized thoracic pathological ossification of the ligamentum flavum: a finite element analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Screening and Predictive Value of Thoracic Ossification Observed on Lateral Radiography for Myelopathy.Yonsei medical journal · 2026Article
- Delayed myelopathy caused by cerebrospinal fluid pseudocyst following decompression for thoracic ossification of the ligamentum flavum: a case report and literature review.BMC musculoskeletal disorders · 2026Review
- Current progress and controversies in thoracic ossification of the ligamentum flavum: pathogenesis, diagnosis and surgical management.Frontiers in surgery · 2026Review
- Article
- Laminoplasty and In-Site Regrafting for the Treatment of Thoracic Ossification of the Ligamentum Flavum: A Surgical Technique.Orthopaedic surgery · 2025Article
- The Quality of Life of the Patients with Thoracic Ossification of the Ligamentum Flavum after Surgery Using EQ-5D-5L.Orthopaedic surgery · 2024Article
- Pathogenesis of thoracic ossification of the ligamentum flavum.Frontiers in pharmacology · 2024Review
- Preoperative Magnetic Resonance Imaging Signal Intensity Classification Is Associated With Clinical Presentation and Surgical Outcomes in Myelopathy Caused by Thoracic Ossification of Ligamentum Flavum: A Multicenter Study.Global spine journal · 2023Article
- CT-based radiographic measurements and effectiveness estimates of full-endoscopic surgery in thoracic myelopathy caused by ossification of ligamentum flavum.BMC surgery · 2023Article
- [Application of unilateral biportal endoscopy technique in single-segment thoracic ossification of ligamentum flavum].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023Article
- Young thoracic vertebra diffuse idiopathic skeletal hyperostosis with Scheuermann disease: A case report.World journal of clinical cases · 2023Article
- PTGR1 is involved in cell proliferation in thoracic ossification of the ligamentum flavum.PloS one · 2023Article
- Article
- LGR5 regulates osteogenic differentiation of human thoracic ligamentum flavum cells by Wnt signalling pathway.Journal of cellular and molecular medicine · 2022Article
- The influence of ossification morphology on surgery outcomes in patients with thoracic ossification of ligamentum flavum (TOLF).Journal of orthopaedic surgery and research · 2022Article
- Long-Term Follow-Up of Multilevel Thoracic Ossification of the Posterior Longitudinal Ligament Following Circumferential Decompression via Posterior Approach: A Retrospective Study.Orthopaedic surgery · 2022Article
- Diffuse Spinal Hyperostosis Causing Severe Spinal Stenosis and Thoracic Myelopathy.Orthopedic reviews · 2022Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thoracic ossification of the ligamentum flavum (TOLF) is the most common cause for thoracic spinal stenosis. TOLF is usually complicated by thoracic disc herniation, ossification of the posterior longitudinal ligament and degenerative spinal diseases such as cervical spondylosis and lumbar spinal stenosis, and the ossification also usually has a discontinuous or continuous multi-segment distribution. The resultant superposition of several symptoms makes the clinical manifestations complex. Currently, the diagnosis of TOLF depends mainly on the patient's symptoms, physical examination and thoracic CT and MRI examinations. Identification of the location of TOLF depends more on the doctor's subjective judgement. Diagnostic problems are related to the specific region and level of surgical decompression: if the extent of decompression is insufficient, the treatment is inadequate, resulting in residual symptoms. Obversely, unnecessary trauma and a various complications will occur if the decompression is too extensive. Hence, the clinical features and process of diagnosis, especially the means of identifying the location, still require further improvement. It is necessary to establish a simple and accurate means of identifying the segment of TOLF that is responsible for the neurologic deficit: a number of spinal surgeons have been working hard on this. This article will provided an overview of the clinical features of TOLF and the related problems of clinical identification of the location of the segment causing the neurological deficit. The relationship between the imaging manifestations and clinical characteristics still need to be explored with the aim of establishing a simple and precise method for determining precisely whether TOLF is related to spinal cord injury or not, thus reducing surgical trauma and achieving an optimal prognosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.